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Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease

  • PHARMACOLOGY AND TOXICOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

Antioxidant activity of a pharmaceutical substance hypocard was compared with activity of nitromalic acid and well-known agents nicorandil and Mexidol. The ability of these substances to inhibit spontaneous and oxidant-induced LPO process in rat brain homogenate was analyzed. The mechanisms of these effects were studied. The antioxidant properties of hypocard manifested in the inhibition of Fe(II)-induced LPO were significantly more pronounced in comparison with Mexidol and nicorandil.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, Moscow, Russia

    M. E. Neganova, S. G. Klochkov & E. F. Shevtsova

  2. Institute of Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    T. N. Bogatyrenko & D. V. Mishchenko

  3. Medical Chemistry Research and Educational Center, Moscow State Regional University, Chernogolovka, Russia

    D. V. Mishchenko

Authors
  1. M. E. Neganova
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  2. S. G. Klochkov
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  3. E. F. Shevtsova
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  4. T. N. Bogatyrenko
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  5. D. V. Mishchenko
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Corresponding author

Correspondence to M. E. Neganova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 53-57, July, 2018

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Neganova, M.E., Klochkov, S.G., Shevtsova, E.F. et al. Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease. Bull Exp Biol Med 166, 46–49 (2018). https://doi.org/10.1007/s10517-018-4286-4

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  • DOI: https://doi.org/10.1007/s10517-018-4286-4

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