Abstract
Background
Opioids are commonly used for general anesthesia, but reflex cough can occur after an intravenous injection. We have performed a meta-analysis of randomized controlled trials (RCTs) that evaluated the effectiveness and safety of prophylactic lidocaine administered intravenously (IV) on opioid-induced cough (OIC) during induction in patients undergoing general anesthesia.
Methods
We searched three bibliographic databases (PubMed, Embase, and the Cochrane Central Register of Controlled Trials) to identify studies meeting a priori inclusion criteria and also conducted a secondary reference review. The information used to calculate the relationship between lidocaine prophylaxis and the risk and severity of OIC was extracted by two principal investigators, respectively.
Results
Six RCTs with a total of 1,740 participants were included in this meta-analysis. Overall, prophylactic lidocaine administered IV reduced both the risk of OIC [pooled risk ratio (RR) 0.471; 95 % confidence interval (CI) 0.355–0.625; P = 0.074; heterogeneity test, I 2 = 50.3 %] and its severity (weighed mean difference −0.316; 95 % CI −0.480 to −0.151; P = 0.038; heterogeneity test, I 2 = 60.5 %). Sub-group analysis indicated a significant reduction in the incidence of both fentanyl-induced cough (FIC) and remifentanil-induced cough (RIC), but it appeared that lidocaine only alleviated the severity of FIC. Further sub-group analysis indicated that the lowest effect dose of lidocaine for preventing the prevalence of OIC was 0.5 mg/kg. No severe adverse effects were reported.
Conclusions
Our meta-analysis establishes the effectiveness of prophylactic lidocaine administered IV for the prevention of OIC during induction. The lowest effective dose of lidocaine on the risk of OIC appeared to be 0.5 mg/kg.
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References
Bohrer H, Fleischer F, Werning P. Tussive effect of a fentanyl bolus administered through a central venous catheter. Anaesthesia. 1990;45:18–21.
Cho HB, Kwak HJ, Park SY, Kim JY. Comparison of the incidence and severity of cough after alfentanil and remifentanil injection. Acta Anaesthesiol Scand. 2010;54:717–20.
Kim JY, Park KS, Kim JS, Park SY, Kim JW. The effect of lidocaine on remifentanil-induced cough. Anaesthesia. 2008;63:495–8.
Bang SR, Ahn HJ, Kim HJ, Kim GH, Kim JA, Yang M, Kim JK, Cho HS. Comparison of the effectiveness of lidocaine and salbutamol on coughing provoked by intravenous remifentanil during anesthesia induction. Korean J Anesthesiol. 2010;59:319–22.
Guler G, Aksu R, Bicer C, Tosun Z, Boyaci A. Comparison of the effects of ketamine or lidocaine on fentanyl-induced cough in patients undergoing surgery: a prospective, double-blind, randomized, placebo-controlled study. Curr Ther Res Clin Exp. 2010;71:289–97.
Lin JA, Yeh CC, Lee MS, Wu CT, Lin SL, Wong CS. Prolonged injection time and light smoking decrease the incidence of fentanyl-induced cough. Anesth Analg. 2005;101:670–4.
Lin CS, Sun WZ, Chan WH, Lin CJ, Yeh HM, Mok MS. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough. Can J Anaesth. 2004;51:654–9.
Oshima T, Kasuya Y, Okumura Y, Murakami T, Dohi S. Identification of independent risk factors for fentanyl-induced cough. Can J Anaesth. 2006;53:753–8.
Tweed WA, Dakin D. Explosive coughing after bolus fentanyl injection. Anesth Analg. 2001;92:1442–3.
Ambesh S, Singh N, Srivastava K. Fentanyl induced coughing caused life-threatening airway obstruction in a patient with arteriovenous malformation of tongue and hypopharynx. Int J Anesthesiol. 2009;20:7.
Hung KC, Chen CW, Lin VC, Weng HC, Hsieh SW. The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing. Anaesthesia. 2010;65:4–7.
Lim JH, Ryu SJ, Lim YS. The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration. Korean J Anesthesiol. 2010;58:117–21.
Kim JY, Nahm FS, Park YO. Limiting peak plasma concentration effectively decreases remifentanil-induced coughing during target-controlled infusion. Anaesth Intensive Care. 2008;36:746.
Ambesh SP, Singh N, Gupta D, Singh PK, Singh U. A huffing manoeuvre, immediately before induction of anaesthesia, prevents fentanyl-induced coughing: a prospective, randomized, and controlled study. Br J Anaesth. 2010;104:40–3.
Lui PW, Hsing CH, Chu YC. Terbutaline inhalation suppresses fentanyl-induced coughing. Can J Anaesth. 1996;43:1216–9.
Agarwal A, Azim A, Ambesh S, Bose N, Dhiraj S, Sahu D, Singh U. Salbutamol, beclomethasone or sodium chromoglycate suppress coughing induced by iv fentanyl. Can J Anaesth. 2003;50:297–300.
Horng HC, Wong CS, Hsiao KN, Huh BK, Kuo CP, Cherng CH, Wu CT. Pre-medication with intravenous clonidine suppresses fentanyl-induced cough. Acta Anaesthesiol Scand. 2007;51:862–5.
Kim JY, Kim JY, Park SY, Jung WS, Kwak HJ. Effect of low dose ketamine to prevent remifentanil-induced cough: a randomize, double-blind, placebo controlled trial. Korean J Anesthesiol. 2009;56:624–7.
Yu MS, Kim JY, Kim HY. Intravenous dexamethasone pretreatment reduces remifentanil induced cough. Korean J Anesthesiol. 2011;60:403–7.
Pandey CK, Raza M, Ranjan R, Singhal V, Kumar M, Lakra A, Navkar DV, Agarwal A, Singh RB, Singh U, Singh PK. Intravenous lidocaine 0.5 mg kg−1 effectively suppresses fentanyl-induced cough. Can J Anaesth. 2005;52:172–5.
Pandey C, Raza M, Ranjan R, Lakra A, Agarwal A, Singh U, Singh R, Singh P. Intravenous lidocaine suppresses fentanyl-induced coughing: a double-blind, prospective, randomized placebo-controlled study. Anesth Analg. 2004;99:1696–8.
Higgins J, Green S (eds). Cochrane handbook for systematic reviews of interventions version 5.0.1 [updated September 2008]. Chichester: Wiley; 2008.
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1–12.
Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med. 2001;135:982–9.
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.
Armitage P, Berry G, Matthews J. Analysing means and proportions: statistical methods in medical research. Oxford: Blackwell Science; 2002. p. 83–146.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.
Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.
Reitan JA, Stengert KB, Wymore ML, Martucci RW. Central vagal control of fentanyl-induced bradycardia during halothane anesthesia. Anesth Analg. 1978;57:31–6.
Yasuda I, Hirano T, Yusa T, Satoh M. Tracheal constriction by morphine and by fentanyl in man. Anesthesiology. 1978;49:117–9.
Benthuysen JL, Smith NT, Sanford TJ, Head N, Dec-Silver H. Physiology of alfentanil-induced rigidity. Anesthesiology. 1986;64:440–6.
Phua WT, The BT, Jong W, Lee TL, Tweed WA. Tussive effect of a fentanyl bolus. Can J Anaesth. 1991;38:330–4.
Hirota K, Hashimoto Y, Sato T, Yoshioka H, Kudo T, Ishihara H, Matsuki A. I.v. lidocaine worsens histamine-induced bronchoconstriction in dogs. Br J Anaesth. 1999;82:87–9.
Nishino T, Hiraga K, Sugimori K. Effects of i.v. lidocaine on airway reflexes elicited by irritation of the tracheal mucosa in humans anaesthetized with enflurane. Br J Anaesth. 1990;64:682–7.
Yukioka H, Hayashi M, Terai T, Fujimori M. Intravenous lidocaine as a suppressant of coughing during tracheal intubation in elderly patients. Anesth Analg. 1993;77:309–12.
Poulton TJ, James FR. Cough suppression by lidocaine. Anesthesiology. 1979;50:470–2.
Han JI. Should the clinical study on opioid-induced cough continue? Korean J Anesthesiol. 2011;60:391–2.
Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surg. 2008;95:1331–8.
Vigneault L, Turgeon AF, Cote D, Lauzier F, Zarychanski R, Moore L, McIntyre LA, Nicole PC, Fergusson DA. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anaesth. 2011;58:22–37.
Jalota L, Kalira V, George E, Shi YY, Hornuss C, Radke O, Pace NL, Apfel CC. Prevention of pain on injection of propofol: systematic review and meta-analysis. BMJ. 2011. doi:10.1136/bmj.d1110.
Tanaka Y, Nakayama T, Nishimori M, Sato Y, Furuya H. Lidocaine for preventing postoperative sore throat. Cochrane Database Syst Rev. 2009. doi:10.1002/14651858.CD004081.
Acknowledgments
We acknowledge Guang Hao, National Center for Cardiovascular Disease Control and Research, Fuwai Hospital, National Heart Center, Chinese Academy of Medical Sciences and Peking Union Medical College, for assistance with the statistical analysis.
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None declared.
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Sun, L., Guo, R. & Sun, L. The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials. J Anesth 28, 325–333 (2014). https://doi.org/10.1007/s00540-013-1732-3
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DOI: https://doi.org/10.1007/s00540-013-1732-3