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The role of microRNA in esophageal squamous cell carcinoma

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Abstract

MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.

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Abbreviations

c-MYC:

Myelocytomatosis viral oncogene homolog

CAF:

Cancer-associated fibroblast

CDK:

Cyclin-dependent kinase

EMT:

Epithelial-to-mesenchymal transition

ERK:

Extracellular signal-regulated kinase

ESCC:

Esophageal squamous cell carcinoma

KRAS:

V-Myc Avian v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

MAPK:

Mitogen-activated protein kinase

miRNA:

microRNAs

mRNA:

Messenger RNA

PDCD4:

Programmed cell death protein 4

PTEN:

Phosphatase and tensin homolog

SOX4:

SRY-related HMG-box 4

TGF-β:

Transforming growth factor beta

TS-miRs:

Tumor-suppressive miRNAs

ZEB1:

Zinc finger E-box-binding homeobox 1

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Kazuto Harada, Yoshifumi Baba, Takatsugu Ishimoto, Hironobu Shigaki, Keisuke Kosumi, Naoya Yoshida & Hideo Baba

  2. Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan

    Masayuki Watanabe

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  1. Kazuto Harada
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Harada, K., Baba, Y., Ishimoto, T. et al. The role of microRNA in esophageal squamous cell carcinoma. J Gastroenterol 51, 520–530 (2016). https://doi.org/10.1007/s00535-016-1161-9

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  • DOI: https://doi.org/10.1007/s00535-016-1161-9

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