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Delivering value from sperm proteomics for fertility

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Abstract

Fertilization of an egg by a spermatozoon sets the stage for mammalian development. Viable sperm are a prerequisite for successful fertilization and beyond. Spermatozoa have a unique cell structure where haploid genomic DNA is located in a tiny cytoplasmic space in the head, mitochondria in the midpiece and then the tail, all enclosed by several layers of membrane. Proteins in sperm play vital roles in motility, capacitation, fertilization, egg activation and embryo development. Molecular defects in these proteins are associated with low fertility or in some cases, infertility. This review will first summarize genesis, molecular anatomy and physiology of spermatozoa, fertilization, embryogenesis and then those proteins playing important roles in various aspects of sperm physiology.

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Authors and Affiliations

  1. Department of Animal and Dairy Sciences, Mississippi State University, Starkville, 39762, MS, USA

    Aruna Govindaraju, Sule Dogan, Kamilah Grant & Erdogan Memili

  2. Grupo Centauro Universidad de Antioquia, Medellin, Colombia

    Nelida Rodriguez-Osorio

  3. Alta Genetics, Inc., Watertown, WI, USA

    Abdullah Kaya

Authors
  1. Aruna Govindaraju
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  2. Sule Dogan
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  3. Nelida Rodriguez-Osorio
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  4. Kamilah Grant
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  5. Abdullah Kaya
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  6. Erdogan Memili
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Corresponding author

Correspondence to Erdogan Memili.

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Govindaraju, A., Dogan, S., Rodriguez-Osorio, N. et al. Delivering value from sperm proteomics for fertility. Cell Tissue Res 349, 783–793 (2012). https://doi.org/10.1007/s00441-012-1452-2

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  • DOI: https://doi.org/10.1007/s00441-012-1452-2

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