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Acrosin, the peculiar sperm-specific serine protease

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Summary

The sperm enzyme acrosin has long been known as one of the key enzymes in the mammalian fertilization process. Elucidation of primary structures of preproacrosin from various species have allowed a deeper insight into the structural organization and the complex evolution of the sperm proteinase acrosin. In addition to the typical elements of serine proteases, the acrosin molecule possesses one novel domain that might convey DNA-binding properties.

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Authors and Affiliations

  1. Institut für Humangenetik der Universität, Gosslerstrasse 12d, W-3400, Göttingen, Germany

    Uwe Klemm & Wolfgang Engel

  2. Institut für Physiologische Chemie und Pathobiochemie der Universität, Duesbergweg 6, W-6500, Mainz, Federal Republic of Germany

    Werner Müller-Esterl

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  1. Uwe Klemm
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  2. Werner Müller-Esterl
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  3. Wolfgang Engel
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Klemm, U., Müller-Esterl, W. & Engel, W. Acrosin, the peculiar sperm-specific serine protease. Hum Genet 87, 635–641 (1991). https://doi.org/10.1007/BF00201716

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  • DOI: https://doi.org/10.1007/BF00201716

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