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Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

An Author Correction to this article was published on 02 May 2018

This article has been updated

Abstract

Introduction

Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. In the past few years, the discovery of inter-genomic crosstalk between nucleus and mitochondria has reinforced the role of mitochondrial DNA variants in perturbing this essential signaling pathway and thus indirectly targeting nuclear genes involved in tumorigenic and invasive phenotype.

Findings

Mitochondrial dysfunction is currently considered a crucial hallmark of carcinogenesis as well as a promising target for anticancer therapy. Mitochondrial DNA alterations include point mutations, deletions, inversions, and copy number variations, but numerous studies investigating their pathogenic role in cancer have provided inconsistent evidence. Furthermore, the biological impact of mitochondrial DNA variants may vary tremendously, depending on the proportion of mutant DNA molecules carried by the neoplastic cells (heteroplasmy).

Conclusions

In this review, we discuss the role of different type of mitochondrial DNA alterations in colorectal carcinogenesis and, in particular, we revisit the issue of whether they may be considered as causative driver or simply genuine passenger events. The advent of high-throughput techniques as well as the development of genetic and pharmaceutical interventions for the treatment of mitochondrial dysfunction in colorectal cancer are also explored.

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Change history

  • 02 May 2018

    The affiliation detail for the corresponding author, Edoardo Errichiello, was published incorrectly. The correct detail read as follows:

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Funding

This study was supported by AIRC—Associazione Italiana per la Ricerca sul Cancro (Grant Number #5982).

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Authors and Affiliations

  1. Department of Molecular Medicine, University of Pavia, Via Forlanini 14, 27100, Pavia, Italy

    Edoardo Errichiello

  2. Molecular Pathology Laboratory, Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS, Starda Provinciale 142, Candiolo, 10060, Turin, Italy

    Edoardo Errichiello & Tiziana Venesio

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  1. Edoardo Errichiello
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  2. Tiziana Venesio
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Correspondence to Edoardo Errichiello.

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EE declares that he has no conflict of interest. TV declares that she has no conflict of interest.

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Errichiello, E., Venesio, T. Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?. J Cancer Res Clin Oncol 143, 1905–1914 (2017). https://doi.org/10.1007/s00432-017-2418-2

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  • DOI: https://doi.org/10.1007/s00432-017-2418-2

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