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TNF-β +252 A>G polymorphism and susceptibility to cancer

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Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Objective

Tumor necrosis factor-β (TNF-β) plays important roles in mediating cancer development. Many studies have argued possible associations of TNF-β +252 A>G polymorphism with different cancers. However, association between this most frequently studied polymorphism and susceptibility to cancer still remains controversial and ambiguous. The aim of this study is to determine the relationship of TNF-β +252 A>G polymorphism with cancer through meta-analysis.

Methods

Electronic searches of several databases were conducted for all publications on the associations between this variant and cancer through October 2011. Odds ratios (ORs) with 95 % confidence intervals (95 % CIs) were used to access the strength of this association in random-effect model.

Results

Thirty-three studies with 14,435 cancer patients and 10,583 healthy controls were included. In this meta-analysis, we detected statistically significant connections between this polymorphism and cancer risks [GG + GA vs. AA: OR = 1.24, 95 % CI = 1.02–1.51; GG vs. AA: OR = 1.43, 95 % CI = 1.05–1.95; G vs. A: OR = 1.28, 95 % CI = 1.28 (1.09–1.50)] in the overall ethnic population. Meanwhile, we detected significant associations in Asian population (GG + GA vs. AA), other population (GG vs. GA + AA), and Caucasian population (GG vs. AA, G vs. A) with the OR values being 1.21 (1.04–1.40), 1.64 (1.35–1.99), 1.65 (1.02, 2.65), and 1.39 (1.09–1.75), respectively.

Conclusions

TNF-β +252 A>G polymorphism is positively associated with susceptibility to cancer. However, this study also suggests that more studies should be conducted to further confirm the associations between this variant and specific types of cancers.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (No. 81202184).

Conflict of interest

The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, 23 Youzheng St., Nangang District, Harbin, 150001, People’s Republic of China

    Lin Yang & Wenbo Wang

  2. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China

    Rennan Feng

  3. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

    Guiyou Liu

  4. School of Life Sciences, Northwest A&F University, Yangling, China

    Mingzhi Liao

  5. Department of Biophysics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Liangcai Zhang

  6. Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Unit 1410, Houston, TX, 77230, USA

    Liangcai Zhang

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  1. Lin Yang
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  2. Rennan Feng
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  3. Guiyou Liu
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  4. Mingzhi Liao
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Correspondence to Liangcai Zhang or Wenbo Wang.

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Yang, L., Feng, R., Liu, G. et al. TNF-β +252 A>G polymorphism and susceptibility to cancer. J Cancer Res Clin Oncol 139, 765–772 (2013). https://doi.org/10.1007/s00432-013-1384-6

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