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Actin complexes in the cell nucleus: new stones in an old field

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Abstract

Actin is a well-known protein that has shown a myriad of activities in the cytoplasm. However, recent findings of actin involvement in nuclear processes are overwhelming. Actin complexes in the nucleus range from very dynamic chromatin-remodeling complexes to structural elements of the matrix with single partners known as actin-binding proteins (ABPs). This review summarizes the recent findings of actin-containing complexes in the nucleus. Particular attention is given to key processes like chromatin remodeling, transcription, DNA replication, nucleocytoplasmic transport and to actin roles in nuclear architecture. Understanding the mechanisms involving ABPs will definitely lead us to the principles of the regulation of gene expression performed via concerting nuclear and cytoplasmic processes.

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Acknowledgments

This work was supported by Czech Science Foundation (Reg. No. 204/07/1592 and student project Reg. No. 204/09/H084), by The Ministry of Education, Youth and Sports of the Czech Republic (Reg. No. LC 545 and 2B06063), and by the institutional grant AV0Z50520514.

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  1. Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the ASCR, v.v.i., Vídeňská 1083, 142 20, Prague 4, Czech Republic

    E. Castano, V. V. Philimonenko, M. Kahle, J. Fukalová, A. Kalendová, S. Yildirim, R. Dzijak, H. Dingová-Krásna & P. Hozák

  2. Biochemistry and Molecular Plant Biology Department, CICY, Calle 43, No.130, Colonia Chuburná de Hidalgo, c.p. 97200, Mérida, Yucatán, Mexico

    E. Castano

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  1. E. Castano
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E. Castano and V. V. Philimonenko contributed equally.

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Castano, E., Philimonenko, V.V., Kahle, M. et al. Actin complexes in the cell nucleus: new stones in an old field. Histochem Cell Biol 133, 607–626 (2010). https://doi.org/10.1007/s00418-010-0701-2

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