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Method to predict the chance of developing a male profile out of mixtures of male and female DNA

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Abstract

In forensic examination it is a standard to take vaginal swabs from victims of sexual assault for further molecular genetic analysis. Laboratories then are usually confronted with mixtures of lots of female and only a small amount of male DNA. Nowadays it is possible to work with specific Y chromosomal markers after DNA extraction by differential lysis. The determined ratio of autosomal DNA and Y chromosomal DNA can be used to identify the possibility of generating a male profile in these samples.

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Authors and Affiliations

  1. Kantonsspital St. Gallen, Institute of Legal Medicine St. Gallen, St. Gallen, Switzerland

    Patrick Johannes Laberke & Roland Hausmann

  2. University of Basel, Institute of Legal Medicine Basel, Basel, Switzerland

    Rahel Grossenbacher & Beate Balitzki

Authors
  1. Patrick Johannes Laberke
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  2. Rahel Grossenbacher
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  3. Roland Hausmann
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  4. Beate Balitzki
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Correspondence to Patrick Johannes Laberke.

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Laberke, P.J., Grossenbacher, R., Hausmann, R. et al. Method to predict the chance of developing a male profile out of mixtures of male and female DNA. Int J Legal Med 126, 157–160 (2012). https://doi.org/10.1007/s00414-011-0615-0

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  • DOI: https://doi.org/10.1007/s00414-011-0615-0

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