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Epigenetic regulation of genomic integrity

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Abstract

Inefficient and inaccurate repair of DNA damage is the principal cause of DNA mutations, chromosomal aberrations, and carcinogenesis. Numerous multiple-step DNA repair pathways exist whose deployment depends on the nature of the DNA lesion. Common to all eukaryotic DNA repair pathways is the need to unravel the compacted chromatin structure to facilitate access of the repair machinery to the DNA and restoration of the original chromatin state afterward. Accordingly, our cells utilize a plethora of coordinated mechanisms to locally open up the chromatin structure to reveal the underlying DNA sequence and to orchestrate the efficient and accurate repair of DNA lesions. Here we review changes to the chromatin structure that are intrinsic to the DNA damage response and the available mechanistic insight into how these chromatin changes facilitate distinct stages of the DNA damage repair pathways to maintain genomic stability.

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We apologize to those in the field whose work we were not able to discuss due to space limitations.

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  1. Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Angela K. Deem, Xuan Li & Jessica K. Tyler

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  1. Angela K. Deem
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  2. Xuan Li
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Correspondence to Jessica K. Tyler.

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Communicated by Erich Nigg

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Deem, A.K., Li, X. & Tyler, J.K. Epigenetic regulation of genomic integrity. Chromosoma 121, 131–151 (2012). https://doi.org/10.1007/s00412-011-0358-1

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