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Prognostic value of systemic ımmune ınflammation ındex in patients with laryngeal cancer

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the systemic immune-inflammation index (SII) with the clinical and pathological parameters of 118 laryngeal cancer patients, as well as their effects on the survival of the disease.

Methods

For the calculation of SII, PLR, and NLR, hemogram tests were conducted before treatment. Receiver-operating characteristic (ROC) analysis was used to calculate the cut-off value of SII, NLR, and PLR for overall survival (OS) and disease-free survival (DFS).

Results

A statistically significant relationship was found between SII and lymphovascular invasion and between NLR and local recurrence, and lymphovascular invasion. In a univariate analysis, SII (p < 0.001) and NLR (p = 0.001) for OS and SII (p < 0.001), PLR (p = 0.043), and NLR (p < 0.001) for DFS were detected as prognostic factors. In a multivariate analysis for OS, SII (HR = 10.54, 95% CI 1.28–86.77; p = 0.029) and extracapsular extension (HR = 3.08, 95% CI 1.15–8.21; p = 0.024) were identified as independent prognostic factors. In a multivariate analysis for DFS, only an extracapsular extension presence (HR = 3.32, 95% CI 1.37–8.08; p = 0.008) was detected as an independent prognostic factor.

Conclusion

In laryngeal cancer, high SII values were determined as poor independent prognostic factors for OS. High SII, NLR, and PRL have been identified as poor prognostic factors in DFS. A correlation was found between NLR and local recurrence, and lymphovascular invasion and between SII with lymphovascular invasion positivity.

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Funding

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Authors and Affiliations

  1. Department of Radiation Oncology, Medical Faculty of Saglik, Bilimleri University, Dr. Abdurrahman Yurtarslan Oncology Research and Training Hospital, Ankara, Turkey

    Ebru Atasever Akkas

  2. Department of Radiation Oncology, Medical Faculty of Cumhuriyet University, Sivas, Turkey

    Birsen Yucel

Authors
  1. Ebru Atasever Akkas
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  2. Birsen Yucel
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by EAA, BY. The first draft of the manuscript was written by EAA and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ebru Atasever Akkas.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

The study was approved by the medical faculty of the University of Health Sciences and the Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital review board (Ethics committee approval was waived, since this is a retrospective study, decision number: 2020-03/565).

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Informed consent was obtained from all individual participants included in the study.

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The authors have read and approved the final manuscript. We warrant that the article is an original article, is not under consideration by another journal, and has not been previously published. Also, we transfer copyright to the Publisher.

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Atasever Akkas, E., Yucel, B. Prognostic value of systemic ımmune ınflammation ındex in patients with laryngeal cancer. Eur Arch Otorhinolaryngol 278, 1945–1955 (2021). https://doi.org/10.1007/s00405-021-06798-2

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  • DOI: https://doi.org/10.1007/s00405-021-06798-2

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