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Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis

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Abstract

Laryngeal cancer is the second most common cancer of the respiratory tract with a relative 5-year survival over all tumour sites in the USA (61.6%; SEER 2009), which is much better than other head and neck cancers. The aim of this paper is to review and summarise data on the survival of laryngeal cancer patients. Literature search was conducted to identify articles in PubMed up to June 2009. Thirty studies with different study aims including sufficient information on survival of laryngeal cancer patients were identified. The 5-year overall survival ranged from 0 to 100%, depending on the T- and N-category, therapeutic approach and tumour location. The involvement of other factors such as genetics, nutrition and lifestyle habits remains uncertain. Our meta-analysis on a subgroup of published studies yielded an overall 5-year relative survival rate of 64.2% (95% confidence interval 63.7–64.7%). Different study aims and patient selection criteria prohibit general conclusions. However, this review may provide an actual picture of the complexity of factors influencing the survival of laryngeal cancer patients.

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Acknowledgments

The work of Elisabeth Rudolph was supported in part by a DFG grant from the GRK 793 Graduate College: “Epidemiology of communicable and chronic, non-communicable diseases and their interrelationships” at the University Hospital at Heidelberg.

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The authors declare no competing interests.

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Authors and Affiliations

  1. Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany

    Elisabeth Rudolph, Heiko Becher & Heribert Ramroth

  2. Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany

    Gerhard Dyckhoff

  3. Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany

    Andreas Dietz

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  1. Elisabeth Rudolph
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Rudolph, E., Dyckhoff, G., Becher, H. et al. Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis. Eur Arch Otorhinolaryngol 268, 165–179 (2011). https://doi.org/10.1007/s00405-010-1395-8

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