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The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma

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Abstract

The aim of this study was to identify the potential prognostic roles of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with laryngeal squamous cell carcinoma (LSCC). 81 patients who underwent surgery for the larynx carcinoma were enrolled in the study. NLR, PLR and RDW were used as outcome measures. Local recurrence was detected in 30 (37.0 %) patients and neck lymph node metastasis was detected 6 (7.4 %) patients during follow-up period. Mortality was seen in 7 (8.6 %) patients. The mean PLR in the T1 and T2 stage tumors were significantly lower than the T4 stage. The mean RDW and PLR were significantly higher in the exitus group than the survivor group. The mean NLR in the patients with local recurrence was significantly higher than the non-recurrent patients. Progression-free survival (PFS) was lower in patients with high NLR. When analyzed by the Cox regression analysis of factors affecting the local recurrence, NLR was found to significantly affect the recurrence. According to ROC analysis for mortality, NLR was not found to be a prognostic factor, although the PLR and RDW were significant prognostic factors. According to Cox regression analysis, a high PLR increases mortality 4.2 times and a high RDW 4.6 times. Although in univariate analysis MCV, RDW and tumor grade were predictors of mortality, RDW and tumor grade independent predictors were found. Further studies involving large patient groups are required.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey

    Medine Kara, Oğuz Güçlü & Fevzi Sefa Dereköy

  2. Department of Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey

    Sema Uysal

  3. Department of Anesthesiology and Reanimation, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey

    Uğur Altinişik

  4. Department of Public Health, Faculty of Medicine, Çanakkale Onsekiz Mart University, Canakkale, Turkey

    Sibel Cevizci

Authors
  1. Medine Kara
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  2. Sema Uysal
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  3. Uğur Altinişik
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  4. Sibel Cevizci
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  5. Oğuz Güçlü
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  6. Fevzi Sefa Dereköy
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Correspondence to Medine Kara.

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The authors declare that they have no conflict of interest.

Ethical statement

This study was conducted with the local ethics committee approved of the study (Date: 11.11.2015 and Approval number: 2015-18). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was not taken from patients because this study was a retrospective chart analysis.

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Kara, M., Uysal, S., Altinişik, U. et al. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 274, 535–542 (2017). https://doi.org/10.1007/s00405-016-4250-8

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  • DOI: https://doi.org/10.1007/s00405-016-4250-8

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