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Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer

  • Head and Neck
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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objectives

Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients.

Methods

We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC. The patients were stratified by PLR into three subgroups: low (≤ 119.55), moderate (> 119.55 and ≤ 193.55), and high (> 193.55). Kaplan–Meier curves were plotted to compare the intergroup cancer-specific survival (CSS).

Results

Patients with high PLR had significantly worse survival outcomes (5-year CSS, low vs. moderate vs. high: 75.3 vs. 68.4 vs. 53.9%; 10-year CSS, low vs. moderate vs. high: 65.0 vs. 56.0 vs. 38.6%, P < 0.001). Patients with PLR > 193.55 represented malnutrition and more advanced cancer stage..

Conclusion

Patients with PLR > 193.55 experience poor outcomes and represent malnutrition, more advanced cancer stage.

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Acknowledgements

We would like to thank the native English speaking scientists of Elixigen Company (Huntington Beach, CA, USA) for editing our manuscript.

Funding

None.

Author information

Author notes

  1. Yize Mao and Yan Fu contributed equally to this work.

Authors and Affiliations

  1. Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China

    Yize Mao

  2. Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, No. 651 Dongfeng Road East, Guangzhou, 510060, China

    Yan Fu, Ankui Yang & Quan Zhang

  3. Department of Otolaryngology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai City, 519020, Guangdong Province, China

    Yunfei Gao

Authors
  1. Yize Mao
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Corresponding author

Correspondence to Quan Zhang.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration.

Electronic supplementary material

Below is the link to the electronic supplementary material.

405_2017_4849_MOESM1_ESM.tif

Supplementary Figure 1 Kaplan–Meier curves for OS of LSCC patients. The blue curve represents the PLR-low group, the green curve represents the PLR-moderate group, and the grey curve represents the PLR-high group. The OS of PLR-high group is significantly shorter than others (5-year OS, low vs. moderate vs. high: 73.5% vs. 66.3% vs. 53.9%; 10-year OS, low vs. moderate vs. high: 60.2% vs. 49.9% vs. 34.6%; P < 0.001) (TIF 2045 KB)

405_2017_4849_MOESM2_ESM.tif

Supplementary Figure 2 (a) PLR correlated with NLR (r = 0.627; P < 0.001). (b) PLR correlated with BMI (r = 0.148; P < 0.001) (TIF 1921 KB)

405_2017_4849_MOESM3_ESM.tif

Supplementary Figure 3 (a) Value of PLR was higher in advanced T stage than early stage (T1 vs. T2 vs. T3 vs. T4: 112.83 vs. 114.29 vs. 127.63 vs. 127.38, P = 0.007). (b) There was no significant difference in PLR values across each N stage (N1 vs. N2 vs. N3 vs. N4: 119.23 vs. 122.00 vs. 127.72 vs. 138.79, P = 0.583) (TIF 1940 KB)

Supplementary Figure 4 Distribution of the number of ages of the patients with PLR > 193.55 (TIF 1014 KB)

405_2017_4849_MOESM5_ESM.tif

Supplementary Figure 5 There was no significant difference in the PLR value for any age group in the PLR-high group (P = 0.632) (TIF 993 KB)

405_2017_4849_MOESM6_ESM.tif

Supplementary Figure 6 (a) Value of ALB was lower in PLR-high group than PLR-low group (PLR-low vs. PLR-high: 43.15 vs. 42.03 g/L, P = 0.016). (b) Value of Hb was lower in PLR-high group than other groups (PLR-low vs. PLR-moderate vs. PLR-high: 142.21 vs. 137.82 vs. 130.87 g/L, P < 0.001) (TIF 6745 KB)

405_2017_4849_MOESM7_ESM.tif

Supplementary Figure 7 Kaplan–Meier curves for CSS of LSCC patients. The blue curve represents the NLR ≤ 2.59 group and the green curve represents the NLR > 2.59 group. The CSS of PLR-high group is significantly shorter than others (5-year OS, ≤ 2.59 vs. > 2.59: 75.9% vs. 64.0%; 10-year OS, ≤ 2.59 vs. > 2.59: 63.6% vs. 53.0%; P = 0.001) (TIF 2791 KB)

Supplementary Table 1 Comorbidities in Patients with different PLR Stage (DOCX 13 KB)

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Mao, Y., Fu, Y., Gao, Y. et al. Platelet-to-lymphocyte ratio predicts long-term survival in laryngeal cancer. Eur Arch Otorhinolaryngol 275, 553–559 (2018). https://doi.org/10.1007/s00405-017-4849-4

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  • DOI: https://doi.org/10.1007/s00405-017-4849-4

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