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The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Purpose

The platelet to lymphocyte ratio (PLR) is a potential prognostic marker in a number of different cancers. The aim of this study was to evaluate the prognostic impact of the PLR in patients with stage II colorectal cancer (CRC) who have undergone curative resection but not adjuvant chemotherapy.

Methods

A retrospective review was performed on 234 patients with stage II CRC who underwent curative resection, but not adjuvant chemotherapy, in our institute. The patients were divided into low and high PLR groups, and patient survival as well as several clinicopathological factors were compared between the groups. Disease-free survival (DFS) and cancer-specific survival (CSS) were analyzed by using the Kaplan–Meier method, and multivariate analysis was performed by using the Cox proportional hazard model.

Results

The cutoff value of the PLR determined by using a receiver-operating characteristic curve analysis was 25.4. DFS and CSS were significantly better in patients with a low PLR compared to patients with a high PLR (P = 0.002 and P = 0.011, respectively). On multivariate analysis, we identified the PLR as an independent prognostic factor for DFS and CSS, with a hazard ratio of 2.65 (95 % confidence interval [CI], 1.26–5.45; P = 0.011) and 3.61 (95 % CI, 1.08–12.64; P = 0.038, respectively).

Conclusions

The PLR is a good prognostic indicator in patients with stage II CRC who have undergone curative surgery but not adjuvant chemotherapy.

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Disclosure

All of authors declare no conflicts of interest or financial ties to disclosure.

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Authors and Affiliations

  1. Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan

    Tsuyoshi Ozawa, Soichiro Ishihara, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Hiroaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama & Toshiaki Watanabe

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  1. Tsuyoshi Ozawa
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  2. Soichiro Ishihara
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  3. Takeshi Nishikawa
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  4. Toshiaki Tanaka
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  8. Kazushige Kawai
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  13. Joji Kitayama
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  14. Toshiaki Watanabe
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Correspondence to Tsuyoshi Ozawa.

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Ozawa, T., Ishihara, S., Nishikawa, T. et al. The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis 30, 1165–1171 (2015). https://doi.org/10.1007/s00384-015-2276-9

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  • DOI: https://doi.org/10.1007/s00384-015-2276-9

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