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Meniscus reconstruction: today’s achievements and premises for the future

  • Arthroscopy and Sports Medicine
  • Published:
Archives of Orthopaedic and Trauma Surgery Aims and scope Submit manuscript

Abstract

Injuries of the meniscus remain a burden for the development of premature cartilage degeneration and osteoarthritis. This review surveys all treatment options and focuses on the recent development of tissue engineering. Tissue engineering of the meniscus means a successful combination of cells, scaffolds and specific stimuli. Each element of the combination can be subject to variation. Studies investigating the optimum meniscus implant and previous steps in producing these implants are presented in this article. A comprehensive search of the English and German literature was performed in PubMed to retrieve appropriate manuscripts for review. Based on the literatures, autografts and allografts can delay the progress of osteoarthritis for a restricted time period, but several concerns persist. The biomechanical properties of the native meniscus are not copied entirely by the current existing autografts. Congruence, fixation, biocompatibility and potential infection will always remain as limitations for the users of allografts. Long-term results are still not available for meniscus prosthesis and even though it permits fast recovery, several aspects are questionable: bioincompatibility and a lack of cellular adhesion are likely to compromise their long-term fate. Currently, there is no ideal implant generated by means of tissue engineering. However, meniscus tissue engineering is a fast developing field, which promises to develop an implant that mimics histological and biomechanical properties of the native meniscus. At present several cell sources and scaffolds have been used successfully to grow 3-dimensional constructs. In future, optimal implants have to be developed using growth factors, modified scaffolds and stimuli that support cellular proliferation and differentiation to regenerate the native meniscus more closely.

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Acknowledgments

This paper has been written entirely by the authors and was supported by “Deutsche Arthrosehilfe” and “Gesellschaft für Orthopädisch-Traumatologische Sportmedizin (GOTS)”. Chaoxu Liu received financial support from the China Scholarship Council (CSC). Ionel Cristian Toma was supported by the Romanian Government and the Trauma Foundation.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopedic Trauma, Hannover Medical School (MHH), OE 6230 Carl-Neuberg-Straße 1, 30625, Hanover, Germany

    Chaoxu Liu, Christian Krettek & Michael Jagodzinski

  2. Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1095, 430030, Wuhan, China

    Chaoxu Liu

  3. Department of Orthopaedic Trauma, Klinikum Ernst von Bergmann, Charlottenstraße 72, 14467, Potsdam, Germany

    Ionel Cristian Toma

  4. Instituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi 10, 16132, Genoa, Italy

    Maddalena Mastrogiacomo

  5. Department of Orthopedics, Hannover Medical School (MHH), Annastift, Anna von Bories Str. 1-7, 30625, Hanover, Germany

    Gabriela von Lewinski

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  1. Chaoxu Liu
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  2. Ionel Cristian Toma
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  3. Maddalena Mastrogiacomo
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Correspondence to Chaoxu Liu.

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Liu, C., Toma, I.C., Mastrogiacomo, M. et al. Meniscus reconstruction: today’s achievements and premises for the future. Arch Orthop Trauma Surg 133, 95–109 (2013). https://doi.org/10.1007/s00402-012-1624-2

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