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T cell-mediated paraneoplastic ganglionitis – An autopsy case

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Abstract

A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.

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Authors and Affiliations

  1. Ludwig Boltzmann Institut für Neuroonkologie Linz, Wagner Jauregg Weg 15, A-4020 Linz, Austria e-mail: marcus.drlicek@wj.lkh.ooe.gv.at, , , , , , AT

    M. Drlicek, A. Bodenteich, S. Urbanits & W. Grisold

  2. Ludwig Boltzmann Institute for Clinical Neurobiology, Baumgartner Höhe 1, A-1145 Vienna, Austria, , , , , , AT

    U. Setinek

  3. Institute of Pathology, Kaiser Franz Josef Spital, Kundratstrasse 3, A-1100 Vienna, Austria, , , , , , AT

    G. Tucek

Authors
  1. M. Drlicek
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  2. A. Bodenteich
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  3. U. Setinek
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  4. G. Tucek
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  5. S. Urbanits
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  6. W. Grisold
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Additional information

Received: 4 May 1999 / Revised: 12 July 1999, 6 September 1999 / Accepted: 7 September

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Drlicek, M., Bodenteich, A., Setinek, U. et al. T cell-mediated paraneoplastic ganglionitis – An autopsy case. Acta Neuropathol 99, 599–602 (2000). https://doi.org/10.1007/s004010051168

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  • DOI: https://doi.org/10.1007/s004010051168

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