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Docetaxel neuropathy: a distal axonopathy

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Abstract

Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m2. Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.

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Authors and Affiliations

  1. Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy e-mail: quattrini.angelo@hsr.it Tel.: +39-02-26433036, Fax: +39-02-26432335, , , , , , IT

    Raffaella Fazio, A. Quattrini, Stefano Previtali, Nicola Canal & Raffaello Nemni

  2. Department of Oncology, San Raffaele Scientific Institute, Milan, Italy, , , , , , IT

    Angelo Bolognesi, Gianni Bordogna & Eugenio Villa

Authors
  1. Raffaella Fazio
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  2. A. Quattrini
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  3. Angelo Bolognesi
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  4. Gianni Bordogna
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  5. Eugenio Villa
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  6. Stefano Previtali
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  7. Nicola Canal
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  8. Raffaello Nemni
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Additional information

Received: 21 January 1999 / Revised, accepted: 25 March 1999

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Fazio, R., Quattrini, A., Bolognesi, A. et al. Docetaxel neuropathy: a distal axonopathy. Acta Neuropathol 98, 651–653 (1999). https://doi.org/10.1007/s004010051132

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  • DOI: https://doi.org/10.1007/s004010051132

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