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Controversies over the staging of α-synuclein pathology in Parkinson’s disease

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References

  1. Attems J, Jellinger KA (2008) The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson’s disease. Neuropathol Appl Neurobiol. doi:10.1111/j.1365-2990.2008.00937.x

  2. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24(2):197–211

    Article  PubMed  Google Scholar 

  3. Braak H, Muller CM, Rub U, Ackermann H, Bratzke H, de Vos RA, Del Tredici K (2006) Pathology associated with sporadic Parkinson’s disease––where does it end? J Neural Transm Suppl 70:89–97

    Article  PubMed  Google Scholar 

  4. Del Tredici K, Rub U, de Vos RA, Bohl JR, Braak H (2002) Where does parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 61(5):413–426

    PubMed  Google Scholar 

  5. Dickson DW, Fujishiro H, Delledonne A, Menke J, Ahmed Z, Klos KJ, Josephs KA, Frigerio R, Burnett M, Parisi JE, Ahlskog JE (2008) Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease. Acta Neuropathol 115(4):437–444

    Article  PubMed  Google Scholar 

  6. Fearnley JM, Lees AJ (1991) Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain 114(Pt 5):2283–2301

    Article  PubMed  Google Scholar 

  7. Hawkes CH, Deeb J (2006) Predicting Parkinson’s disease: worthwhile but are we there yet? Pract Neurol 6:272–277

    Google Scholar 

  8. Hawkes CH, Del TK, Braak H (2007) Parkinson’s disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol 33(6):599–614

    Article  PubMed  CAS  Google Scholar 

  9. Jellinger KA (2003) Alpha-synuclein pathology in Parkinson’s and Alzheimer’s disease brain: incidence and topographic distribution––a pilot study. Acta Neuropathol 106(3):191–201

    Article  PubMed  Google Scholar 

  10. Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RK (2007) The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson’s disease: a critical analysis of alpha-synuclein staging. Neuropathol Appl Neurobiol. doi:10.1111/j.1365-2990.2007.00923.x

  11. Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S, Przuntek H, Epplen JT, Schols L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nat Genet 18(2):106–108

    Article  PubMed  CAS  Google Scholar 

  12. Meredith GE, Sonsalla PK, Chesselet MF (2008) Animal models of Parkinson’s disease progression. Acta Neuropathol 115(4):385–398

    Article  PubMed  Google Scholar 

  13. Parkkinen L, Kauppinen T, Pirttila T, Autere JM, Alafuzoff I (2005) Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia. Ann Neurol 57(1):82–91

    Article  PubMed  CAS  Google Scholar 

  14. Parkkinen L, Pirttila T, Alafuzoff I (2008) Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol 115(4):399–407

    Article  PubMed  Google Scholar 

  15. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di IG, Golbe LI, Nussbaum RL (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276(5321):2045–2047

    Article  PubMed  CAS  Google Scholar 

  16. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839–840

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Ronald K. B. Pearce.

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Kalaitzakis, M.E., Graeber, M.B., Gentleman, S.M. et al. Controversies over the staging of α-synuclein pathology in Parkinson’s disease. Acta Neuropathol 116, 125–128 (2008). https://doi.org/10.1007/s00401-008-0381-3

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  • DOI: https://doi.org/10.1007/s00401-008-0381-3

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