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Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry

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Abstract

Background

The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge® (Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.

Methods

A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.

Results

In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (p < 0.05 versus below 10 mmol/L).

Conclusion

The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Department of Medicine, University Hospital Düsseldorf, Düsseldorf, Germany

    Maryna Masyuk, Ralf Westenfeld, Malte Kelm & Christian Jung

  2. Division of Cardiology, Pneumology and Critical Care Medicine, Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

    Peter Abel & Stephan B. Felix

  3. Department of Cardiology, Pulmonology and Internal Intensive Care Medicine, Städtisches Klinikum München GmbH, Klinikum Neuperlach, Munich, Germany

    Martin Hug

  4. Department of Cardiology, Paracelsus Medical University, Salzburg, Austria

    Bernhard Wernly

  5. Department of Cardiovascular Surgery, University of Schleswig, Holstein Campus Kiel, Kiel, Germany

    Assad Haneya

  6. Department of Cardiology, Pneumology, and Internal Intensive Care Medicine, Schwabing Hospital, Academic Municipal Hospital Munich, Munich, Germany

    Stefan Sack

  7. Department of Cardiovascular Surgery, German Heart Center, Technische Universität München (TUM), Munich, Germany

    Konstantinos Sideris

  8. Medical Clinic I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

    Nicolas Langwieser

  9. Department of Cardiology, Angiology, Intensive Care Medicine, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany

    Tobias Graf & Georg Fuernau

  10. Department of Cardiology, Clinic of Internal Medicine I, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany

    Marcus Franz

  11. CARID: Cardiovascular Research Institute Düsseldorf, Düsseldorf, Germany

    Malte Kelm

  12. DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany

    Stephan B. Felix

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  1. Maryna Masyuk
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  2. Peter Abel
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  3. Martin Hug
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  6. Stefan Sack
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  10. Georg Fuernau
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  11. Marcus Franz
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  15. Christian Jung
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Correspondence to Christian Jung.

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Masyuk, M., Abel, P., Hug, M. et al. Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry. Clin Res Cardiol 109, 46–53 (2020). https://doi.org/10.1007/s00392-019-01482-2

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  • DOI: https://doi.org/10.1007/s00392-019-01482-2

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