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Intracranial aneurysms in adolescents

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Abstract

Purpose

Intracranial aneurysms are extremely uncommon in adolescents. This study was undertaken to assess the clinical and radiological characteristics and clarify the choice of therapeutic strategies of intracranial aneurysms in adolescents with age range from 15 to 18 years.

Methods

From our dedicated aneurysmal databank between October 1985 and July 2008, we reviewed 16 consecutive adolescents who had 20 intracranial aneurysms.

Results

Ten boys and six girls (male/female ratio = 1.67:1; mean age 16.78 ± 1.18 years) were included in the present study. Intracranial aneurysms in adolescents constituted 0.91% of all intracranial aneurysms. It was found that 25% of the lesions were in the posterior circulation, while 75% of the lesions were in the anterior circulation, and 25% developed on the middle cerebral artery (MCA). Half of the patients presented with subarachnoid hemorrhage and others mainly presented with mass effect such as weakness in the extremities, diplopia, and dysfunction of eye movement. Eight cases underwent endovascular treatment: including GDC therapy in five patients, parental artery occlusion in two patients, and cover stent implantation in one patient with pseudoaneurysm of the cavernous segment of the left internal carotid artery. Four patients received microsurgical therapy: aneurismal neck clipping for two patients and extracranial–intracranial (EC–IC) bypass and trapping of complex aneurysms in MCA for the other two patients. Four patients did not receive microsurgical or endovascular therapy, including a boy whose aneurysm spontaneously thrombosed preoperatively and a girl who died before operation because of rerupture of aneurysm. Two patients did not undergo therapy owing to the high operative risk. All of the patients who received therapy had favorable outcome (GOS 4 or 5) at discharge and at follow-up.

Conclusions

Intracranial aneurysms in adolescents differ from those in adults in many ways including the following: male predominance; high incidence of large or giant, traumatic, dissecting, and fusiform aneurysms; high incidence of aneurysms in the posterior circulation; high incidence of spontaneous thrombosis; better Hunt–Hess grade at presentation; and better therapeutic outcome. Both microsurgical approaches and endovascular treatment were effective. For some giant, complex intracranial aneurysms, parent artery occlusion or EC–IC bypass is the best treatment choice.

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Authors and Affiliations

  1. Department of Neurosurgery, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing, 100191, China

    Jian-tao Liang & Zhen-yu Wang

  2. Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing, 100053, China

    Jian-tao Liang, Yu-hai Bao, Hong-qi Zhang & Feng Ling

  3. Cerebrovascular Diseases Research Institute, 45 Changchun Street, Beijing, 100053, China

    Jian-tao Liang, Yu-hai Bao, Hong-qi Zhang & Feng Ling

  4. Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China

    Li-rong Huo

Authors
  1. Jian-tao Liang
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  2. Li-rong Huo
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  3. Yu-hai Bao
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  4. Hong-qi Zhang
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  5. Zhen-yu Wang
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  6. Feng Ling
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Corresponding authors

Correspondence to Zhen-yu Wang or Feng Ling.

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Liang, Jt., Huo, Lr., Bao, Yh. et al. Intracranial aneurysms in adolescents. Childs Nerv Syst 27, 1101–1107 (2011). https://doi.org/10.1007/s00381-010-1334-4

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  • DOI: https://doi.org/10.1007/s00381-010-1334-4

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