Abstract
A highly fecund inbred mouse line has been established from the Quackenbush Swiss (QS) outbred strain by full-sib inbreeding combined with selection for high number of pups born alive (NBA) and low interlitter interval (ILI). After more than 50 generations of inbreeding and selection, this line, named QSi5, has an NBA of 13.4 and an ILI of 29 days, averaged over the first four parities, and a total productivity of 50.7 NBA. With its exceptional reproductive performance, this line will be very useful in the creation of resources (including advanced intercross lines) for analysis of quantitative trait loci for a wide range of traits, and for the cost-effective creation of congenic lines.
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Acknowledgments
A very special thanks goes to Jennifer Kirton who was heavily involved in the early, critical generations of the breeding program. Thanks also go to Dr. Pradeepa Silva, who kindly provided background information on the derivation of the sublines, and to Zung Doan, who transferred the data into electronic form. Laboratory Animal Services, University of Sydney, arranged genotyping of the QSi5 mice for allozyme markers by Dr. Mark Adams, Evolutionary Biology Unit, SA Museum, North Terrace, Adelaide, SA, as part of routine quality control of mouse strains.
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Holt, M., Nicholas, F.W., James, J.W. et al. Development of a highly fecund inbred strain of mice. Mamm Genome 15, 951–959 (2004). https://doi.org/10.1007/s00335-004-3030-8
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DOI: https://doi.org/10.1007/s00335-004-3030-8