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Magnetic resonance coronary angiography with vasovist™: in-vivo T 1 estimation to improve image quality of navigator and breath-hold techniques

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Abstract

The purpose of the study was to estimate T 1 values of blood and myocardium after a single injection of Vasovist™ and to assess Vasovist™ for magnetic resonance coronary angiography (MRCA). For all exams 0.05 mmol/kg of Vasovist™ was injected. T 1 values of blood and myocardium were estimated over 30 min after injection. Twelve volunteers were examined on a 1.5-T Siemens system using a SSFP sequence with incrementally increasing inversion times for T 1-estimation and a breath-hold 3D IR-FLASH sequence for MRCA. Eleven examinations were performed on 1.5-T Philips system using the Look-Locker approach for T 1 estimation and a whole-heart inversion-prepared, 3D SSFP sequence for MRCA. SNR, CNR and image quality were assessed. T 1 values of blood (5 min: 230 ms vs. 30 min: 275 ms) and myocardium (5 min: 99 ms vs. 30 min: 130 ms) increased over time. Whereas the blood SNR (1 min: 23.6 vs. 30 min: 21.2) showed no significant differences, the blood-to-myocardium CNR (1 min: 18.1 vs. 30 min: 13.8) and the image quality (1 min: 2.9 vs. 30 min: 3.8) degraded over time. Due to long plasma half-time the T1-shortening effect of Vasovist™ remains effective over 30 min, which allows for multiple breath-hold or high-resolution MRCA.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45122, Essen, Germany

    Kai Nassenstein, Kai-Uwe Waltering, Thomas Schlosser, Stefan Maderwald, Peter Hunold & Jörg Barkhausen

  2. Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Berlin, Germany

    Sebastian Kelle & Eike Nagel

  3. Department of Cardiology, West German Heart Center, University Hospital Essen, Essen, Germany

    Frank Breuckmann

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  1. Kai Nassenstein
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  2. Kai-Uwe Waltering
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  3. Sebastian Kelle
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  4. Thomas Schlosser
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  5. Frank Breuckmann
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  6. Stefan Maderwald
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  7. Peter Hunold
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  8. Eike Nagel
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  9. Jörg Barkhausen
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Correspondence to Jörg Barkhausen.

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Nassenstein, K., Waltering, KU., Kelle, S. et al. Magnetic resonance coronary angiography with vasovist™: in-vivo T 1 estimation to improve image quality of navigator and breath-hold techniques. Eur Radiol 18, 103–109 (2008). https://doi.org/10.1007/s00330-007-0720-0

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  • DOI: https://doi.org/10.1007/s00330-007-0720-0

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