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Association of osteopontin with osteoarthritis

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Abstract

The joint disease osteoarthritis (OA) is the most common form of arthritis, which mainly affects the older people. OA is becoming one of the major non-fatal health burdens of the world. The etiology of OA is mostly unclear, and it cannot be cured totally. Osteopontin (OPN) is a multifunctional phosphoprotein, of which overexpression and high level of presence in synovial fluid and articular cartilage were found to be associated with OA progression. Usually, in OA progression, OPN plays important role as an intrinsic regulator. Recent studies have taken attempt to use this protein as a diagnostic marker of OA and use OPN as a target for the drug development against OA. This review summarizes the role of OPN in OA, with focusing on the mechanism of action, and also discussing the diagnostic and therapeutic aspects of OA related to OPN.

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Acknowledgments

This study was supported by the Grants from the National 863 Project of China (2011AA030101), National Natural Science Foundation of China (Nos. 81201420, 81272034), the Young Teacher’s boosting project of the Fundamental Research Funds for the Central Universities in Central South University (2012QNZT103, 2012QNZT095) and National Clinical Key Department Construction Projects of China.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Orthopaedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China

    Chao Cheng, Shuguang Gao & Guanghua Lei

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  1. Chao Cheng
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  2. Shuguang Gao
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  3. Guanghua Lei
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Correspondence to Guanghua Lei.

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Cheng, C., Gao, S. & Lei, G. Association of osteopontin with osteoarthritis. Rheumatol Int 34, 1627–1631 (2014). https://doi.org/10.1007/s00296-014-3036-9

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  • DOI: https://doi.org/10.1007/s00296-014-3036-9

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