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Microbiota-Pain Association; Recent Discoveries and Research Progress

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Abstract

The relationship between gut microbiota and pain, such as visceral pain, headaches (migraine), itching, prosthetic joint infection (PJI), chronic abdominal pain (CAP), joint pain, etc., has received increasing attention. Several parts of the evidence suggest that microbiota is one of the most important pain modulators and they can regulate pain in the central and peripheral nervous systems. Any alteration in microbiota by diet or antibiotics mediation may characterize a novel therapeutic strategy for pain management. The present study includes the most up-to-date and influential scientific findings on the association of microbiota with pain, despite the fact that the underlying mechanism is not identified in most cases. According to recent research, identifying the molecular mechanisms of the microbiota-pain pathway can have a unique perspective in treating many diseases, even though there is a long way to reach the ideal point. This study will stress the influence of microbiota on the common diseases that can stimulate the pain with a focus on underlying mechanisms.

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Acknowledgements

The authors would like to thank the Aging Research Institute and the Physical Medicine Rehabilitation Research Center of Tabriz University of Medical Sciences.

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Authors and Affiliations

  1. Department of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

    Naser Alizadeh & Ghazal Naderi

  2. Department of Surgery, Alborz University of Medical Sciences, Karaj, Alborz, Iran

    Mohammad saeed Kahrizi

  3. Aging Research Institute, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 51664, Iran

    Tannaz Haghgouei & Ahmad Mobed

  4. Division of Pharmacology and toxicology Department of Basic Sciences, Faculty of Veterinary Medicine University of Tabriz, Tabriz, Iran

    Tannaz Haghgouei

  5. Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Ahmad Mobed

  6. Department of Surgery, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran

    Mehran Ebrahimi shah-abadi

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  1. Naser Alizadeh
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  2. Ghazal Naderi
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  3. Mohammad saeed Kahrizi
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  4. Tannaz Haghgouei
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  5. Ahmad Mobed
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  6. Mehran Ebrahimi shah-abadi
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Contributions

AM; Writing and editing original draft, NA: Writing and editing original draft, GN: Writing original draft and tables drawing, MsK: Writing and editing original draft, TH: Writing and editing original draft, MEs-a: Writing and editing original draft.

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Correspondence to Ahmad Mobed or Mehran Ebrahimi shah-abadi.

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Alizadeh, N., Naderi, G., Kahrizi, M.s. et al. Microbiota-Pain Association; Recent Discoveries and Research Progress. Curr Microbiol 80, 29 (2023). https://doi.org/10.1007/s00284-022-03124-9

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