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Resolution of allergic asthma

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Abstract

Allergic asthma is an inflammatory disease of the airways characterized by recurrent episodes of wheezing and bronchoconstriction. Chronic inflammation may finally lead to structural damage followed by airway remodeling. Various studies in recent years contributed to unravel important aspects of the immunopathogenesis of asthma and adapted new pharmaceutical developments. Here, I consider some novel insights into the immunopathogenesis of asthma and the protective and pathogenic roles of some innate and adaptive immune cells as well as the function of soluble mediators such as cytokines. Particular attention will be given to new concepts on resolution of chronic airway inflammation for prevention of airway structural damage.

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Acknowledgments

The author thanks Julia Kölle, Adriana Geiger, Susanne Mittler, Eveldina Nendel, and Sonja Trump for their assistance and continuous commitment to our scientific research.

Funding

This work was also supported by a DFG grant FI817/6-1 awarded to Susetta Finotto and by the SFB1181.

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  1. Department of Molecular Pneumology, University of Erlangen-Nürnberg, Kussmaul Campus for Medical Research, Hartmannstr. 14, 91054, Erlangen, Germany

    Susetta Finotto

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Correspondence to Susetta Finotto.

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This article is a contribution to the special issue on Resolution of Inflammation in Chronic Diseases - Guest Editor: Markus Neurath

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Finotto, S. Resolution of allergic asthma. Semin Immunopathol 41, 665–674 (2019). https://doi.org/10.1007/s00281-019-00770-3

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