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Peritoneal Infusion with Cold Saline Decreased Postoperative Intra-Abdominal Adhesion Formation

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Abstract

Background

Postoperative intra-abdominal adhesion is a common morbidity after laparotomy. We try to determine whether peritoneal infusion with cold saline may decrease postoperative intra-abdominal adhesion formation.

Methods

Ninety-six male BALB/c mice weighing 25-30 g were randomized into four groups: (I) adhesion model with infusion of 4°C cold saline, (II) adhesion model with infusion of room temperature saline, (III) adhesion model without infusion of saline, and (IV) sham operation without infusion of saline. Adhesion scores, incidence of adhesion, and serum cytokines were measured at postoperative days 1, 3, 7, and 14.

Results

Group I had lower adhesion scores than groups II and III (P < 0.0001). IL-6, IL-10, and TNF-α were significantly increased in the groups I, II, and III compared to group IV (P < 0.0001). IL-6 in group I was significantly decreased compared to that in group III (P < 0.0004). IL-10 in group I was significantly increased compared to that in groups II (P < 0.0001) and III (P < 0.05). TNF-α in group I was significantly decreased compared to that in groups II (P < 0.0004), and III (P < 0.05).

Conclusion

Peritoneal infusion with cold saline may decrease the degree of postoperative intra-abdominal adhesion formation.

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Acknowledgment

This study was partly supported by the National Science Council Grant NSC 93-2314-B-002-260.

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Authors and Affiliations

  1. Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Road, Taipei, 10016, Taiwan

    Cheng-Chung Fang, Tzung-Hsin Chou, Geng-Shiau Lin, Zui-Shen Yen, Chien-Chang Lee & Shyr-Chyr Chen

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  1. Cheng-Chung Fang
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  2. Tzung-Hsin Chou
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Correspondence to Shyr-Chyr Chen.

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Fang, CC., Chou, TH., Lin, GS. et al. Peritoneal Infusion with Cold Saline Decreased Postoperative Intra-Abdominal Adhesion Formation. World J Surg 34, 721–727 (2010). https://doi.org/10.1007/s00268-009-0378-7

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  • DOI: https://doi.org/10.1007/s00268-009-0378-7

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