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Overview of a bioremediation tool: organophosphorus hydrolase and its significant application in the food, environmental, and therapy fields

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Abstract

In the past decades, the organophosphorus compounds had been widely used in the environment and food industries as pesticides. Owing to the life-threatening and long-lasting problems of organophosphorus insecticide (OPs), an effective detection and removal of OPs have garnered growing attention both in the scientific and practical fields in recent years. Bacterial organophosphorus hydrolases (OPHs) have been extensively studied due to their high specific activity against OPs. OPH could efficiently hydrolyze a broad range of substrates both including the OP pesticides and some nerve agents, suggesting a great potential for the remediation of OPs. In this review, the microbial identification, molecular modification, and practical application of OPHs were comprehensively discussed.

Key points

• Microbial OPH is a significant bioremediation tool against OPs.

• Identification and molecular modification of OPH was discussed in detail.

• The applications of OPH in food, environmental, and therapy fields are presented.

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Funding

This project is financially supported by the National Key R&D Program of China (2019YFC1604602).

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China

    Sumao Zhao, Wei Xu, Wenli Zhang, Hao Wu, Cuie Guang & Wanmeng Mu

  2. International Joint Laboratory On Food Safety, Jiangnan University, Wuxi, 214122, China

    Wanmeng Mu

Authors
  1. Sumao Zhao
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  2. Wei Xu
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  3. Wenli Zhang
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  4. Hao Wu
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  5. Cuie Guang
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  6. Wanmeng Mu
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Contributions

SZ: data analysis, writing—original draft; WX: writing—review and editing; WZ: methodology; HW: software; CG: supervision; WM: co-supervision and project administration; all authors read and approved the manuscript.

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Correspondence to Wei Xu or Cuie Guang.

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Zhao, S., Xu, W., Zhang, W. et al. Overview of a bioremediation tool: organophosphorus hydrolase and its significant application in the food, environmental, and therapy fields. Appl Microbiol Biotechnol 105, 8241–8253 (2021). https://doi.org/10.1007/s00253-021-11633-z

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  • DOI: https://doi.org/10.1007/s00253-021-11633-z

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