Abstract
Quorum sensing (QS) is an important protective mechanism that allows bacteria to adapt to its environment. A limited number of signal molecules play the key role of transmitting information in this mechanism. Signals are transmitted between individual bacterium through QS systems, resulting in the expression of specific genes. QS plays an important role in a variety of bacterial processes, including drug resistance, biofilm formation, motility, adherence, and virulence. Most Gram-positive and Gram-negative bacteria possess QS systems, mainly the LuxS/AI-2-mediated QS system. Evidence has been brought that LuxS/AI-2 system controls major virulence determinants in Streptococcus suis and, as such, the ability of this bacterial species to cause infections in humans and pigs. Understanding the S. suis LuxS/AI-2 system may open up novel avenues for decreasing the drug resistance and infectivity of S. suis. This article focuses on the progress made to date on the S. suis LuxS/AI-2-mediated QS system.
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Acknowledgements
This study was funded by the National Key Research and Development Program of China (No. 2018YFD0500100), the National Natural Science Foundation of China (31772761, 31540095), the Science and Technology Development Project of Henan Province (182300410047, 162300410067), and the China Scholarship Council (CSC).
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YW and LY designed the concept of the review article. YXW, YW, and LYS contributed to writing the manuscript. DG critically read and corrected the manuscript. All authors read and approved the final manuscript.
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Wang, Y., Wang, Y., Sun, L. et al. The LuxS/AI-2 system of Streptococcus suis. Appl Microbiol Biotechnol 102, 7231–7238 (2018). https://doi.org/10.1007/s00253-018-9170-7
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DOI: https://doi.org/10.1007/s00253-018-9170-7