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Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives

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Abstract

Avermectins (AVMs), produced by Streptomyces avermitilis MA-4680 (or ATCC 31267, NRRL 8165, NCBIM 12804), are 16-member macrocylic lactones that play very important functions as bactericidal and antiparasitic agents against nematodes and anthropods, as well as Mycobacterium tuberculosis H37Rv. Since its discovery in 1975, use of AVM has been widely spreading around the globe. To date, the whole genome sequence of S. avermitilis K139 has been acquired, in which the AVM biosynthetic gene cluster was the most highly investigated to mine the genes responsible for functional as well as regulatory roles. Therefore, significant progress has been achieved for understanding and manipulating the biosynthesis, improved production, regulation mechanism, side effects, as well as the resistance of AVMs and their derivatives. These findings will facilitate further strain improvement and biosynthesis of novel derivatives bearing stable and improved biological activities, as well as overcoming the resistance mechanism to open up a bright period for these compounds. In this review, we have summarized and analyzed the update in advanced progress in biochemistry and biotechnological approaches used for the production of AVMs and their derivatives.

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Acknowledgements

This study was supported by the Intelligent Synthetic Biology Center of Global Frontier Project funded by the Ministry of Education, Science and Technology (2011-0031960) and by the grant from the Next-Generation BioGreen 21 Program (JKS: PJ0094832), Rural Development Administration, and Republic of Korea.

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Authors and Affiliations

  1. Center for Molecular Biology, Institute of Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam

    Nguyen Huy Thuan

  2. Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, No. 100 Kalsan-ri, Tangjeong-myeon, Asan-si, Chungnam, 336-708, Republic of Korea

    Ramesh Prasad Pandey & Jae Kyung Sohng

Authors
  1. Nguyen Huy Thuan
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  2. Ramesh Prasad Pandey
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  3. Jae Kyung Sohng
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Correspondence to Nguyen Huy Thuan or Jae Kyung Sohng.

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Thuan, N.H., Pandey, R.P. & Sohng, J.K. Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. Appl Microbiol Biotechnol 98, 7747–7759 (2014). https://doi.org/10.1007/s00253-014-5926-x

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  • DOI: https://doi.org/10.1007/s00253-014-5926-x

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