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Microbial production of poly(hydroxybutyrate) from C1 carbon sources

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An Erratum to this article was published on 14 April 2013

Abstract

Polyhydroxybutyrate (PHB) is an attractive substitute for petrochemical plastic due to its similar properties, biocompatibility, and biodegradability. The cost of scaled-up PHB production inhibits its widespread usage. Intensive researches are growing to reduce costs and improve thermomechanical, physical, and processing properties of this green biopolymer. Among cheap substrates which are used for reducing total cost of PHB production, some C1 carbon sources, e.g., methane, methanol, and CO2 have received a great deal of attention due to their serious role in greenhouse problem. This article reviews the fundamentals of strategies for reducing PHA production and moves on to the applications of several cheap substrates with a special emphasis on methane, methanol, and CO2. Also, some explanation for involved microorganisms including the hydrogen-oxidizing bacteria and methanotrophs, their history, culture condition, and nutritional requirements are given. After description of some important strains among the hydrogen-oxidizing and methanotrophic producers of PHB, the article is focused on limitations, threats, and opportunities for application and their future trends.

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Authors and Affiliations

  1. Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Science, P.O. Box 19395-4741, Tehran, Iran

    Kianoush Khosravi-Darani

  2. Department of Chemical Engineering, School of Petroleum and Petrochemical Engineering, Hakim Sabzevari University, Sabzevar, Iran

    Zahra-Beigom Mokhtari

  3. Department of Biological and Environmental Chemistry, Faculty of Humanity-Oriented Science and Engineering, Kinki University, Kayanomori, Iizuka-si, Fukuoka, 820-8555, Japan

    Tomohito Amai & Kenji Tanaka

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Khosravi-Darani, K., Mokhtari, ZB., Amai, T. et al. Microbial production of poly(hydroxybutyrate) from C1 carbon sources. Appl Microbiol Biotechnol 97, 1407–1424 (2013). https://doi.org/10.1007/s00253-012-4649-0

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