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Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs

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A Correction to this article was published on 07 July 2018

This article has been updated

Abstract

The function of the chicken’s major histocompatibility complex (MHC or B complex) class I major (BF2) and minor (BF1) glycoproteins is compared for their expression, ability to present viral antigens to cytotoxic T lymphocytes (CTLs), and interaction with natural killer (NK) cells. MHC-restricted CTLs recognized virus antigen in the context of the BF2*21 major glycoprotein but not the BF1*21 minor glycoprotein. Marek’s disease virus (MDV), a large DNA virus known to reduce the cell surface expression of class I glycoprotein, reduced the expression of BF2 glycoprotein while BF1glycoprotein expressions are remained as no change or slight increase. In addition, the expression of BF1*21 class I glycoprotein protected target cells from NK cell lysis while the expression of the BF2*21 class I glycoprotein enhanced NK cell lysis of target cells. Therefore, BF1 and BF2 provide two different cellular immune functions; BF1 negatively regulates the NK cell killing activity and BF2 restricts the antigen specific CTL immune response.

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Change history

  • 07 July 2018

    The Figure 3 in the original version of this article was incorrectly published. In this article the top panel of Figure 3 that describes the amino acid sequence alignment is now added. The original article has been corrected.

Abbreviations

B complex:

(chicken MHC-B)

BF:

(chicken MHC class I)

ALV:

(avian leukosis virus)

MDV:

(Marek’s disease virus)

ADOL:

(Avian Disease and Oncology Laboratory)

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Acknowledgements

We would like to acknowledge Dr. Terry Lemme and Dr. Noah Koller for excellent technical assistance. The authors would like to extend many thanks to Dr. Jim Kaufman for helpful review of this manuscript.

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Authors and Affiliations

  1. United States Department of Agriculture, Agricultural Research Service, U.S. National Poultry Research Center, 934 College Station Rd., Athens, GA, 30605, USA

    Taejoong Kim & Henry D. Hunt

  2. Department of Animal and Food Science, University of Delaware, Newark, DE, 19717, USA

    Mark S. Parcells

  3. Department of Pathobiology, Auburn University, 264 Green Hall, Auburn, AL, 36849, USA

    Vicky van Santen

  4. Department of Poultry Science, Auburn University, 105 Poultry Annex Building, Auburn, AL, 36849, USA

    Sandra J. Ewald

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  1. Taejoong Kim
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Correspondence to Taejoong Kim or Henry D. Hunt.

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The original version of this article was revised: The top panel of Figure 3 that describes the amino acid sequence alignment had been missing and is now added in this article.

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Kim, T., Hunt, H.D., Parcells, M.S. et al. Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs. Immunogenetics 70, 599–611 (2018). https://doi.org/10.1007/s00251-018-1066-2

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