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The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L

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Abstract

Mammalian immunoregulatory families of genes encoding activating and inhibitory Ig-like receptor pairs have been located on distinct chromosomes. In chicken, a single Ig-like receptor family with many members had been described so far. By looking at sequence similarity and synteny conservations in the chicken genome, the signal-regulatory protein (SIRP), triggering receptor expressed on myeloid cells (TREM), and CMRF35/CD300L Ig-like gene families were identified on chromosomes 20, 26, and 3, respectively. Further analysis of the three corresponding genomic regions and partial bacterial artificial chromosome sequencing were used to identify more members and to realign several contigs. All putative genomic sequences were monitored by investigating existing expressed sequence tag and cloning cDNA. This approach yielded a single pair of activating and inhibitory SIRP, two inhibitory, and one activating TREM as well as one inhibitory CMRF35/CD300L with a potentially soluble variant and an additional member lacking categorizing motifs. The CMRF35/CD300L and TREM receptors were composed of one or two V-set Ig domains, whereas in SIRP, either a single Ig V domain was present or a combination of a V and C1 domains. Like in many Ig superfamily members, separate exons encode individual Ig domains. However, in two CMRF35/CD300L genes, the signal peptide and the distal Ig domain were encoded by a single exon. In conclusion, the mammalian diversity of immunoregulatory molecules is present the chicken suggesting an important role for TREM, SIRP, and CMRF35/CD300L in a functionally conserved network.

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Abbreviations

CD300L:

CD300 antigen like

CHIR:

Chicken Ig-like receptor

DAP:

DNAX activating protein

ITIM:

Immunoreceptor tyrosine-based inhibitory motif

KARAP:

Killer cell-activating receptor-associated protein

KIR:

Killer cell Ig-like receptor

LILR:

Leukocyte Ig-like receptor

NCR2:

Natural cytotoxicity triggering receptor 2

NILT:

Novel Ig-like transcript

NITR:

Novel immune-type receptor

PILR:

Paired Ig-like type 2 receptor

SHP:

Src homology 2 domain containing protein tyrosine phosphatase

SIRP:

Signal-regulatory protein

TREM:

Triggering receptor expressed on myeloid cells

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Acknowledgements

We cordially thank Drs. L. du Pasquier and M. Groenen for helpful discussions. The BAC clones were provided by the BACPAC Resources of the Children’s Hospital Oakland.

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Authors and Affiliations

  1. Institute for Animal Physiology, University of Munich, Veterinärstr. 13, Munich, 80539, Germany

    Birgit C. Viertlboeck, Ramona Schmitt & Thomas W. Göbel

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  1. Birgit C. Viertlboeck
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  2. Ramona Schmitt
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  3. Thomas W. Göbel
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Correspondence to Thomas W. Göbel.

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Viertlboeck, B.C., Schmitt, R. & Göbel, T.W. The chicken immunoregulatory receptor families SIRP, TREM, and CMRF35/CD300L. Immunogenetics 58, 180–190 (2006). https://doi.org/10.1007/s00251-006-0091-8

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  • DOI: https://doi.org/10.1007/s00251-006-0091-8

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