Abstract
Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction fragments for Mhc class I and/or class II genes has been found among DNA samples collected from birds homozygous for a single serologically defined B haplotype. Such findings have been interpreted as evidence for variability within the Mhc haplotypes of chickens not detected previously with serological methods. In this study of a fully pedigreed family over three generations, the heterogeneity observed in restriction fragment patterns was found to be the result of the presence of a second, independently segregating polymorphic Mhc-like locus, designated Rfp-Y. Three alleles (haplotypes) are identified in this new system.
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Albertson, D. G., Fishpool, R., Sherrington, P., Nacheva, E., and Milstein, C. Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. EMBO J 7: 2801–2805, 1988
Bitgood, J. and Somes, Jr, R. G. Linkage relationships and gene mapping. In R. D. Crawford (ed.): Poultry Breeding and Genetics, pp. 469–495, Elsevier, NeW York, 1990
Bloom, S. E. and Bacon, L. D. Linkage of the major histocompatibility (B) locus and the nucleolar organizer in the chicken: assignment to a microchromosome. J Hered 76: 146–154, 1985
Bradbury, A., Milstein, C., and Kozak, C.A. Chromosomal localization of Cd1d genes in the mouse. Somat Cell Mol Genet 17: 93–96, 1991
Briles, W. E. and Briles, R. W. Some recent recombinations at the B locus. In A. A. Benedict (ed.) Avian Immunology: Advances in Experimental Medicine and Biology 88, pp. 221–225, Plenum Press, New York, 1977
Briles, W. E. and Briles, R. W. A search for “duplicate” recombinants between the B-F and B-G regions of the chicken B complex. Anim Blood Groups Biochem Genet 11 (suppl. 1): 38–39, 1980
Briles, W. E. and Briles, R. W. Identification of haplotypes of the chicken major histocompatibility complex (B). Immunogenetics 15: 449–459, 1982
Briles, W. E., Briles, R. W., and Toth, S. T. Histocompatibility shifts following recombination between B alloantigen subloci. Genetics 91 (suppl.): S14, 1979
Briles, W. E., Bumstead, N., Ewert, D. L., Gilmour, D. G., Gogusev, H., Hála, K., Koch, C., Longenecker, B. M., Nordskog, A. W., Pink, J. R. L., Schierman, L. W., Simonsen, M., Toivanen, A., Toivanen, P., Vainio, O., and Wick, G. Nomenclature for chicken major histocompatibility (B) complex. Immunogenetics 15: 441–447, 1982
Briles, W. E., McGibbon, W. H., and Irwin, M. R. On multiple alleles effecting cellular antigens in the chicken. Genetics 35: 633–652, 1950
Bourlet, Y., Béhar, G., Guillemot, F., Fréchin, N., Billault, A., Chaussé, A.-M., Zoorob, R., and Auffray, C. Isolation of the chicken major histocompatibility complex class II (B-L) β chain sequences: comparison with mammalian β chains and expression in lymphoid organs. EMBO J 7: 1031–1039, 1988
Calabi, F. and Milstein, C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. Nature 323: 540–543, 1986
Carter, C. A., Murphy, G., and Fabre, J. W. A polymorphic HLA-DPA-like locus, unlinked to the rat major histocompatibility complex. Immunogenetics 34: 277–280, 1991
Chaussé, A.-M., Coudert, F., Dambrine, G., Guillemot, F., Miller, M. M., and Auffray, C. Molecular genotyping of four chicken B-complex haplotypes with B-Lκ, B-F, and B-G probes. Immunogenetics 29: 127–130, 1989
Chaussé, A. M., Thoraval, P., Coudert, F., Auffray, C., and Dambrine, G. Analysis of B complex polymorphism in Rous sarcoma progressor and regressor chickens with B-G, B-F, and B-Lβ probes. Avian Dis 34: 934–940, 1990
Dominquez-Steglich, M., Auffray, C., and Schmid, M. Linkage of the chicken MHC to the nucleolus organizer region visualized using non-isotopic in situ hybridization. J Hered 82: 503–505, 1991
Goto, R., Miyada, C. G., Young, S., Wallace, R. B., Abplanalp, H., Bloom, S. E., Briles, W. E., and Miller, M. M. Isolation of a cDNA clone from the B-G subregion of the chicken histocompatibility (B) complex. Immunogenetics 27:102–109, 1988
Guillemot, F., Billault, A., Pourquié, O., Béhar, G., Chaussé, A.-M., Zoorob, R., Kreibich, G., and Auffray, CC. A molecular map of the chicken major histocompatibility complex: the class II β genes are closely linked to the class I genes and nucleolar organizer. EMBO J 7: 2775–2785, 1988
Guillemot, F., Turnel, P., Charron, D., Le Dourain, N., and Auffray, C. Structure, biosynthesis and polymorphism of chicken MHC class II (B-L) antigens and associated molecules. J Immunol 137: 1251–1271, 1986
Hála, K., Sgonc, R., Auffray, C., and Wick, G. Typing of MHC haplotypes in OS chickens by means of RFLP analysis. Prog Clin Biol Res 307: 177–186, 1989
Kaufman, J,, Salomonsen, J., Skjødt, K., and Thorpe, D. Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic hepated repeat region. Proc Natl Acad Sci USA 87: 8277–8281, 1990
Kaufman, J., Skjødt, K., and Salomonsen, J. The MHC molecules of nonmammalian vertebrates. Immunol Rev 113: 82–117, 1990
Kroemer, G., Bernot, A., Béhar, G., Chaussé, A.-M., GAstinel, L.-N, Guillemot, F., Park, I., Thoraval, P., Zoorob, R., and Auffray, C. Molecular genetics of the chicken MHC: current status and evolutionary aspects. Immunol Rev 113: 119–145, 1990
Miller, M. M., Abplanalp, H., and Goto, R. Genotyping chickens for the B-G subregion of the major histocompatibility complex using restriction fragment length polymorphisms. Immunogenetics 28: 374–379, 1988
Miller, M. M., Goto, R., Young, S., Chirivella, J., Hawke, D., and Miyada, C. G. Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken. Proc Natl Acad Sci USA 88: 4377–4381, 1991
Pink, J. R. L., Droege, W., Hála, K., Miggiano, V. C., and Ziegler, A. A three-locus model for the chicken major histocompatibility complex. Immunogenetics 5: 203–216, 1977
Schierman, L. W. and Nordskog, A. W. Relationship of blood type to histocompatibility in chickens. Science 134: 1008–1009, 1961
Tilanus, M. G., Vrielink-van Ginkel, R., Engelen, I., Rietveld, F. W., Hempkema, B. G., van der Zipp, A. J., Egberts, E., and Blankert, H. The chicken B-complex in commercial pure lines: comparison of polymorphisms defined by serotyping and DNA analysis. Prog Clin Biol Res 307: 187–196, 1989
Zoorob, R., Béhar, G., Kroemer, G., and Auffray, C. Organization of a functional chicken class II B gene. Immunogenetics 31: 179–187, 1990
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Briles, W.E., Goto, R.M., Auffray, C. et al. A polymorphic system related to but genetically independent of the chicken major histocompatibility complex. Immunogenetics 37, 408–414 (1993). https://doi.org/10.1007/BF00222464
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DOI: https://doi.org/10.1007/BF00222464