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Diversity of MHC class I genes in Burmese-origin rhesus macaques

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Abstract

Rhesus macaques (Macaca mulatta) are widely used in developing a strategy for vaccination against human immunodeficiency virus by using simian immunodeficiency virus infection as a model system. Because the genome diversity of major histocompatibility complex (MHC) is well known to control the immune responsiveness to foreign antigens, MHC loci in Indian- and Chinese-origin macaques used in the experiments have been characterized, and it was revealed that the diversity of MHC in macaques was larger than the human MHC. To further characterize the diversity of Mamu-A and Mamu-B loci, we investigated a total of 73 different sequences of Mamu-A, 83 sequences of Mamu-B, and 15 sequences of Mamu-I cDNAs isolated from Burmese-origin macaques. It was found that there were one to five expressing genes in each locus. Among the Mamu-A, Mamu-B, and Mamu-I sequences, 44 (60.2%), 45 (54.2%), and 8 (53.3%), respectively, were novel, and most of the other known alleles were identical to those reported from Chinese- or Indian-origin macaques, demonstrating a genetic mixture between the geographically distinct populations of present day China and India. In addition, it was found that a Mamu haplotype contained at least two highly transcribed Mamu-A genes, because multiple Mamu-A1 cDNAs were obtained from one haplotype. These findings further revealed the diversity and complexity of MHC locus in the rhesus macaques.

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Acknowledgments

We thank Miss Yukiko Ueda for technical assistance. This work was supported in part by research grants from the Ministry of Health, Labor and Welfare, Japan; the Japan Health Science Foundation; the program of Founding Research Centers for Emerging and Reemerging Infection Disease; Grant-in-Aids for Scientific research from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan; and research grants from Heiwa Nakajima Foundation, Japan and from Life Science Institute of Seizon-Kagaku Foundation, Japan.

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Authors and Affiliations

  1. Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

    Taeko K. Naruse, Zhiyong Chen, Tomoko Yamashita & Akinori Kimura

  2. Laboratory of Genome Diversity, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan

    Risa Yanagida, Yusuke Saito & Akinori Kimura

  3. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan

    Kazuyasu Mori

  4. Primate Research Institute, Kyoto University, Inuyama, 484-8506, Japan

    Hirofumi Akari

  5. Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Ibaraki, 305-0843, Japan

    Yasuhiro Yasutomi

  6. Department of Immunology, Kinki University School of Medicine, Osaka-Sayama, 589-8511, Japan

    Masaaki Miyazawa

  7. International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan

    Tetsuro Matano

Authors
  1. Taeko K. Naruse
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  2. Zhiyong Chen
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  3. Risa Yanagida
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  4. Tomoko Yamashita
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  5. Yusuke Saito
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  6. Kazuyasu Mori
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  7. Hirofumi Akari
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  8. Yasuhiro Yasutomi
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  9. Masaaki Miyazawa
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  10. Tetsuro Matano
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  11. Akinori Kimura
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Correspondence to Akinori Kimura.

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Naruse, T.K., Chen, Z., Yanagida, R. et al. Diversity of MHC class I genes in Burmese-origin rhesus macaques. Immunogenetics 62, 601–611 (2010). https://doi.org/10.1007/s00251-010-0462-z

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  • DOI: https://doi.org/10.1007/s00251-010-0462-z

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