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Altered Prostaglandin E1 Dosage During Extracorporeal Membrane Oxygenation in a Newborn with Ductal-dependent Congenital Heart Disease

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Abstract

We describe a neonate with ductal-dependent congenital heart disease on extracorporeal membrane oxygenation (ECMO) for persistent pulmonary hypertension, who required markedly high doses of prostaglandin E1 (PGE1) to maintain patency of the ductus arteriosus: The effects of ECMO on the pharmacokinetics of PGE1 are discussed.

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Authors and Affiliations

  1. Division of Cardiology, Carman Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI, 48201, USA

    D.M. Stone & K. Chintala

  2. Division of Clinical Pharmacology, Carman Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI, 48201, USA

    D.A.C. Frattarelli

  3. Division of Pediatrics, Carman Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI, 48201, USA

    S. Karthikeyan

  4. Division of Neonatology, Carman Ann Adams Department of Pediatrics, Children’s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI, 48201, USA

    Y.R. Johnson

Authors
  1. D.M. Stone
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  2. D.A.C. Frattarelli
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  3. S. Karthikeyan
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  4. Y.R. Johnson
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  5. K. Chintala
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Correspondence to D.M. Stone.

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Stone, D., Frattarelli, D., Karthikeyan, S. et al. Altered Prostaglandin E1 Dosage During Extracorporeal Membrane Oxygenation in a Newborn with Ductal-dependent Congenital Heart Disease. Pediatr Cardiol 27, 360–363 (2006). https://doi.org/10.1007/s00246-005-1189-8

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  • DOI: https://doi.org/10.1007/s00246-005-1189-8

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