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Perfusion-weighted techniques in MRI grading of pediatric cerebral tumors: efficiency of dynamic susceptibility contrast and arterial spin labeling

  • Paediatric Neuroradiology
  • Published:
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Abstract

Purpose

Dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) perfusion MRI are applied in pediatric brain tumor grading, but their value for clinical daily practice remains unclear. We explored the ability of ASL and DSC to distinguish low- and high-grade lesions, in an unselected cohort of pediatric cerebral tumors.

Methods

We retrospectively compared standard perfusion outcomes including blood volume, blood flow, and time parameters from DSC and ASL at 1.5T or 3T MRI scanners of 46 treatment-naive patients by drawing ROI via consensus by two neuroradiologists on the solid portions of every tumor. The discriminant abilities of perfusion parameters were evaluated by receiver operating characteristic (ROC) over the entire cohort and depending on the tumor location and the magnetic field.

Results

ASL and DSC parameters showed overall low to moderate performances to distinguish low- and high-grade tumors (area under the curve: between 0.548 and 0.697). Discriminant abilities were better for tumors located supratentorially (AUC between 0.777 and 0.810) than infratentorially, where none of the metrics reached significance. We observed a better differentiation between low- and high-grade cancers at 3T than at 1.5-T. For infratentorial tumors, time parameters from DSC performed better than the commonly used metrics (AUC ≥ 0.8).

Conclusion

DSC and ASL show moderate abilities to distinguish low- and high-grade brain tumors in an unselected cohort. Absolute value of K2, TMAX, tMIP, and normalized value of TMAX of the DSC appear as an alternative to conventional parameters for infratentorial tumors. Three Tesla evaluation should be favored over 1.5-Tesla.

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Data availability

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Author notes

  1. Girard N and Stellmann JP contributed equally to the creation of this manuscript—the order of their names is arbitrary.

Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, APHM La Timone, 264 Saint Pierre Street, 13385, CEDEX 05, Marseille, France

    B. Testud, G. Brun, J. F. Hak & N. Girard

  2. APHM La Conception, Department of Medical Imaging, Aix Marseille Université, Marseille, France

    A. Varoquaux

  3. Department of Pathology and Neuropathology, APHM La Timone, Marseille, France

    R. Appay

  4. Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France

    R. Appay

  5. Aix-Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France

    A. Le Troter, N. Girard & J. P. Stellmann

  6. APHM La Timone, CEMEREM, Marseille, France

    A. Le Troter & J. P. Stellmann

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  1. B. Testud
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  2. G. Brun
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Contributions

Benoit Testud: conception and design of the study, acquired and analyzed the data, drafted the manuscript and the figures. Gilles Brun: conception and design of the study, drafted the manuscript and the figures. Arthur Varoquaux: conception and design of the study, analyzed the data. Jean-François Hak: conception and design of the study. Romain Appay: conception and design of the study. Arnaud Le Troter: analyzed the data. Nadine Girard: conception and design of the study, acquired the data, drafted the manuscript and the figures. Jan-Patrick Stellmann: conception and design of the study, analyzed the data, drafted the manuscript and the figures.

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Correspondence to B. Testud.

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Testud, B., Brun, G., Varoquaux, A. et al. Perfusion-weighted techniques in MRI grading of pediatric cerebral tumors: efficiency of dynamic susceptibility contrast and arterial spin labeling. Neuroradiology 63, 1353–1366 (2021). https://doi.org/10.1007/s00234-021-02640-y

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