Abstract
Introduction
In a previous study using streamlined diffusion tensor imaging (DTI) axonal tracking at 1.5 T, we found that the main afferents to the human red nucleus arise from the sensorimotor and prefrontal cortices. However, the spatial resolution of our data was low and our streamlining DTI algorithm was less powerful than the probabilistic tractography algorithm usually used to define connections between low anisotropic cortical or nuclear areas. Therefore, we reassessed and completed our previous results with trajectories computed with a probabilistic algorithm and with a high-field MRI system.
Methods
Afferents to the red nuclei of five volunteers were studied at 3 T using probabilistic DTI axonal tracking.
Results
Trajectories were constantly tracked between the red nucleus and the ipsilateral prefrontal, pericentral, temporal and occipital cortices, and the ipsilateral lentiform and contralateral dentate nuclei. We showed that the dentate nucleus was connected to the mammillary tubercle and, through the contralateral ventral thalamus, to the frontal and prefrontal cortices.
Conclusion
The red nucleus receives extensive projections from the cerebral cortex and has dense subcortical connections to the striopallidal system.
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References
ten Donkelaar HJ (1988) Evolution of the red nucleus and the rubrospinal tract. Behav Brain Res 28:9–20
Barton RA, Harvey PH (2000) Mosaic evolution of brain structure in mammals. Nature 405:1055–1058
Habas C, Cabanis EA (2006) Cortical projections to the human red nucleus: a diffusion tensor tractography study with a 1.5-T MRI machine. Neuroradiology 48:755–762
Massion J (1967) The mammalian red nucleus. Physiol Rev 47:383–436
Humphrey DR, Gold R, Reed DJ (1984) Sizes, laminar and topographic origins of cortical projections to the major divisions of the red nucleus in the monkey. J Comp Neurol 225:75–94
Keifer J, Houk JC (1994) Motor function of the cerebellorubrospinal system. Physiol Rev 74:509–542
Von Monakow C (1895) Experimentelle und pathologisch-anatomische Untersuchungen über die Haubenregion, den Schlügel und die Regio subthalamica nebst Beiträge zur Kenntnis früh erworbener Gross- und Kleinhirndefecte. Arch Psychiat Nervenkr 27:1–128, 386–478
Archambault L (1914–1915) Les connexions corticales du noyau rouge. Nouv Iconogr Salpêtrière 27:188–225
Meyer M (1949) Study of efferent connexions of the frontal lobe in the human brain after leucotomy. Brain 72:265–296
Kanki S, Ban T (1952) Corticofugal connections of the frontal lobe in man. Med J Osaka Univ 3:201–222
Lehéricy S, Ducros M, Krainik A, François C, Van de Moortele PF, Ugurbil K, Kim DS (2004) 3-D diffusion tensor axonal tracking shows distinct SMA and pre-SMA projections to the human striatum. Cerebral Cortex 14:1302–1309
Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA et al (2003) Non-invasive mappings of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 6:750–757
Behrens TE, Woolrich MW, Jenkinson M, Johansen-Berg H, Nunes RG, Clare S, Matthews PM, Brady JM, Smith SM (2003) Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn Reson Med 50:1077–1088
Tuch DS (2002) Diffusion MRI of complex tissue structure. PhD thesis, Harvard-MIT
Tuch SD (2004) Q-ball imaging. Magn Reson Med 52:577–582
Behrens TEJ, Berg HJ, Jbabdi S, Rushworth MF, Woolrich MW (2006) Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage 34:144–155
Nieuwenhuys R, Voogt J, van Huijzen C (eds) (1988) The human central nervous system. A synopsis and atlas, 3rd revised edn. Springer, Berlin
Déjérine J (1980) Anatomie des centres nerveux. Tome deuxième. Masson, Paris
Johnson TN, Clemente CD (1959) An experimental study of the fibre connections between the putamen, globus pallidus, ventral thalamus and midbrain tegmentum in cat. J Comp Neurol 113:83–101
Burchinskaya LF, Sukhareva NN (1988) Rubrocaudate projections in the cat. Neurophysiology 20:22–25
Carpenter MB (1956) A study of the red nucleus in the rhesus monkey. Anatomical degenerations and physiologic effects resulting from localized lesions of the red nucleus. J Comp Neurol 105:195–249
Foix C, Nicolesco J (1925) Les noyaux gris centraux et la région mésencéphalo-sousoptique. Masson, Paris, p 581
Hopkins DA, Lawrence DC (1975) On the absence of a rubrothalamic projection in the monkey with observations on some ascending mesencephalic projections. J Comp Neurol 161:269–294
Middleton FA, Strick PL (2000) Basal ganglia and cerebellar loops: motor active and cognitive circuits. Brain Res Rev 31:236–250
Morel A, Magnin M, Jeanmonod D (1997) Multiarchitectonic and stereotactic atlas of the human thalamus. J Comp Neurol 387:588–630
Haines DE, Dietrichs E (1990) Neuronal connections between the cerebellar nuclei and hypothalamus in Macaca fascicularis: cerebello-visceral circuits. J Comp Neurol 299:106–122
Patt S, Gerhard L, Zill E (1994) A Golgi study on the red nucleus in man. Histol Histopathol 9:7–10
King JS, Schwyn RC, Fox CA (1971) The red nucleus in the monkey (Macaca mulatta): a Golgi and an electron microscopy study. J Comp Neurol 142:75–107
Massion J (1988) Red nucleus: past and future. Behav Brain Res 28:1–8
Schmahmann JD, Sherman JC (1998) The cerebellar cognitive affective syndrome. Brain 121:561–579
Snider RS (1950) Recent contributions to the anatomy and physiology of the cerebellum. Arch Neurol Psychiatr 64:196–219
Xu D, Liu T, Ashe J, Bushara KO (2006) Role of the olivo-cerebellar system in timing. J Neurosci 26:5990–5995
Ramnani N, Behrens TE, Johansen-Berg H, Richter MC, Pinsk MA, Andersson JL et al (2005) The evolution of the prefrontal inputs to the cortico-pontine system: diffusion imaging evidence from Macaque monkeys and humans. Cereb Cortex 16:811–818
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Habas, C., Cabanis, E.A. Cortical projection to the human red nucleus: complementary results with probabilistic tractography at 3 T. Neuroradiology 49, 777–784 (2007). https://doi.org/10.1007/s00234-007-0260-y
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DOI: https://doi.org/10.1007/s00234-007-0260-y