Abstract
A flow-injection chemiluminescence method for the determination of isoniazid based on the sensitizing effect of isoniazid on the chemiluminescence generating luminol-hypochlorite reaction is described. The hypochlorite was electrogenerated on-line by constant current electrolysis, thus, eliminating instability of hypochlorite solution prepared from commercially available sodium hypochlorite. The calibration graph is linear in the range 1 × 10–8 to 1 × 10–6 g mL–1, and the detection limit is 6 × 10–9 g mL–1. The relative standard deviation for determination of 5 × 10–8 g mL–1 is 2.8%. The proposed method has been successfully applied to the determination of isoniazid in pharmaceutical preparations.
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Reveived: 2 May 1998 / Revised: 27 July 1998 / Accepted: 7 August 1998
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Huang, J., Zhang, C. & Zhang, Z. Flow injection chemiluminescence determination of isoniazid with electrogenerated hypochlorite. Fresenius J Anal Chem 363, 126–128 (1999). https://doi.org/10.1007/s002160051155
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DOI: https://doi.org/10.1007/s002160051155