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Nanomaterial-based aptamer biosensors for ochratoxin A detection: a review

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Abstract

Ochratoxin A (OTA) is a widely distributed mycotoxin that often contaminates food, grains and animal feed. It poses a serious threat to human health because of its high toxicity and persistence. Therefore, the development of an inexpensive, highly sensitive, accurate and rapid method for OTA detection is imperative. In recent years, various nanomaterials used in the establishment of aptasensors have attracted great attention due to their large surface-to-volume ratio, good stability and facile preparation. This review summarizes the development of nanomaterial-based aptasensors for OTA determination and sample treatment over the past 5 years. The nanomaterials used in OTA aptasensors include metal, carbon, luminescent, magnetic and other nanomaterials. Finally, the limitations and future challenges in the development of nanomaterial-based OTA aptasensors are reviewed and discussed.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China [Grant No. 931702218, 31701694], The Young and Middle-aged Leading Scientists, Engineers and Innovators of the XPCC (Grant No. 2019CB017), Natural Science Foundation of Henan Province [Grant No. 202300410121, 182300410038], Foundation for University Young Key Teacher Program of Henan Province [Grant No. 2018GGJS048], and the Youth Talent Support Project of Henan Province [Grant No. 112020HYTP029].

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  1. Xiujin Chen and Dong Gao contributed equally to this work. Zhaozhou Li and Yao Wang contributed equally to this work.

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  1. College of Food and Bioengineering, National Demonstration Center for Experimental Food Processing and Safety Education, Engineering Center of Food Material, Henan University of Science and Technology, NO. 263 Kaiyuan Avenue, Luolong District, Luoyang, 471000, Henan, China

    Xiujin Chen, Dong Gao, Zhaozhou Li, Yao Wang, Caixia Qiu, Kaifeng He & Jing Wang

  2. School of Food Science and Technology, Shihezi University, Shihezi, 832003, Xinjiang, China

    Fengxia Sun

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  1. Xiujin Chen
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Chen, X., Gao, D., Sun, F. et al. Nanomaterial-based aptamer biosensors for ochratoxin A detection: a review. Anal Bioanal Chem 414, 2953–2969 (2022). https://doi.org/10.1007/s00216-022-03960-5

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