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Polydopamine: surface coating, molecular imprinting, and electrochemistry—successful applications and future perspectives in (bio)analysis

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Abstract

Dopamine oxidation and self-polymerization have recently attracted great interest arising from the versatile chemistry of this endogenous catecholamine. Particularly interesting are the applications of polydopamine for surface coating, molecular imprinting, and electrochemistry, which are reviewed here, covering the broad fields of medicine, materials science, and (bio)analytical chemistry. Nonetheless, the peculiar physicochemical properties of dopamine and polydopamine, due to the redox potential of the catechol moiety, are not fully exploited. We have confidence in increasing the applications of dopamine through a large variety of research approaches, including the use of naturally occurring or synthetic dopamine analogues and copolymers. Accordingly, our efforts in this direction are focused on proposing a role for polydopamine in quantitative applications, evaluating analytical performance, cost, reproducibility, and versatility of the methods developed, and also revisiting standard (bio)analytical platforms.

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Acknowledgements

The authors thank the Ministry of Education, University and Research (MIUR) for financial support through the scientific program SIR2014 Scientific Independence of Young Researchers (RBSI1455LK), Horizon 2020, European Union funding for research and innovation, and Regione Toscana for the scientific program Plasmonic Biosensor Analysis of Nucleic Acid Biomarkers (PLABAN; D53D16002290009).

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  1. Department of Chemistry ‘Ugo Schiff’, University of Florence, via della Lastruccia 3–13, 50019, Sesto Fiorentino, FI, Italy

    Pasquale Palladino, Francesca Bettazzi & Simona Scarano

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  1. Pasquale Palladino
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  2. Francesca Bettazzi
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  3. Simona Scarano
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Correspondence to Simona Scarano.

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Published in the topical collection Young Investigators in (Bio-)Analytical Chemistry with guest editors Erin Baker, Kerstin Leopold, Francesco Ricci, and Wei Wang.

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Palladino, P., Bettazzi, F. & Scarano, S. Polydopamine: surface coating, molecular imprinting, and electrochemistry—successful applications and future perspectives in (bio)analysis. Anal Bioanal Chem 411, 4327–4338 (2019). https://doi.org/10.1007/s00216-019-01665-w

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  • DOI: https://doi.org/10.1007/s00216-019-01665-w

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