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Simultaneous determination of NOGE-related and BADGE-related compounds in canned food by ultra-performance liquid chromatography–tandem mass spectrometry

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Abstract

An improved analytical method enabling rapid and accurate determination and identification of bisphenol F diglycidyl ether (novolac glycidyl ether 2-ring), novolac glycidyl ether 3-ring, novolac glycidyl ether 4-ring, novolac glycidyl ether 5-ring, novolac glycidyl ether 6-ring, bisphenol A diglycidyl ether, bisphenol A (2,3-dihydroxypropyl) glycidyl ether, bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether, bisphenol A bis(3-chloro-2-hydroxypropyl) ether, and bisphenol A (3-chloro-2-hydroxypropyl) (2,3-dihydroxypropyl) ether in canned food and their contact packaging materials has been developed by using, for the first time, ultra-performance liquid chromatography coupled with tandem mass spectrometry. After comparison of electrospray ionization and atmospheric pressure chemical ionization in positive and negative-ion modes, tandem mass spectrometry with positive electrospray ionization was chosen to carry out selective multiple reaction monitoring analysis of novolac glycidyl ethers, bisphenol A diglycidyl ether, and its derivatives. The analysis time is only 5.5 min per run. Limits of detection varied from 0.01 to 0.20 ng g−1 for the different target compounds on the basis of a signal-to-noise ratio (S/N) = 3; limits of quantitation were from 0.03 to 0.66 ng g−1. The relative standard deviation for repeatability was <8.01%. Analytical recovery ranged from 87.60 to 108.93%. This method was successfully applied to twenty samples of canned food and their contact packaging materials for determination of migration of NOGE, BADGE, and their derivatives from can coatings into food.

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Acknowledgement

This work was supported by 2010C32G2050021 project of Science Technology Department of Zhejiang Province, Y3100689 project of Zhejiang Natural Science Foundation, and the China Canned Food Industry Association (CCFIA).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. School of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou, 310035, China

    Hong Zhang, Yanyan Zou & Zhiyuan Dai

  2. Hangzhou Center for Disease Control and Prevention, Hangzhou, 310006, China

    Ming Xue

  3. China Canned Food Industry Association, Beijing, 100036, China

    Kunhui Lin

Authors
  1. Hong Zhang
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  2. Ming Xue
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  3. Yanyan Zou
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  4. Zhiyuan Dai
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  5. Kunhui Lin
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Correspondence to Hong Zhang.

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Zhang, H., Xue, M., Zou, Y. et al. Simultaneous determination of NOGE-related and BADGE-related compounds in canned food by ultra-performance liquid chromatography–tandem mass spectrometry. Anal Bioanal Chem 398, 3165–3174 (2010). https://doi.org/10.1007/s00216-010-4284-5

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  • DOI: https://doi.org/10.1007/s00216-010-4284-5

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