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Elemental mass spectrometry for quantitative proteomics

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Abstract

In the last decade mass-spectrometry-based proteomics has become an indispensable analytical tool for molecular biology, cellular biology and, lately, for the emerging systems biology. This review summarises the evolution and great potential of analytical methods based on elemental mass-spectrometric detection for quantitative proteomic analysis.

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Abbreviations

2D:

two-dimensional

AFP:

α-Fetoprotein

CE:

capillary electrophoresis

ESI:

electrospray ionisation

GE:

gel electrophoresis

HPLC:

high-performance liquid chromatography

ICAT:

isotope-coded affinity tags

ICP:

inductively coupled plasma

IDA:

isotope dilution analysis

IgG:

immunoglobulin G

LA:

laser ablation

LC:

liquid chromatography

μLC:

capillary liquid chromatography

MALDI:

matrix-assisted laser desorption and ionisation

MS:

mass spectrometry

MT:

metallothionein

SEC:

size-exclusion chromatography

SILAC:

stable isotope labelling by amino acids in cell cultures

SFMS:

sector field mass spectrometry

T3:

triiodothyronine

T4:

thyroxine

References

  1. Ong SE, Mann M (2005) Nat Chem Biol 1:252–262

    Article  CAS  Google Scholar 

  2. Aebersold R, Mann M (2003) Nature 422:198–207

    Article  CAS  Google Scholar 

  3. Sadygov RG, Cociorva D, Yates JR (2004) Nat Methods 1:195–202

    Article  CAS  Google Scholar 

  4. Wysocki VH, Resing KA, Zhang Q, Cheng G (2005) Methods 35:211–222

    Article  CAS  Google Scholar 

  5. Currie LA (1995) Pure Appl Chem 67:1699–1723

    Article  CAS  Google Scholar 

  6. Zhang H, Yan W, Aebersold R (2004) Curr Opin Chem Biol 8:66–75

    Article  CAS  Google Scholar 

  7. Linscheid MW (2005) Anal Bioanal Chem 381:64–66

    Article  CAS  Google Scholar 

  8. Unwin RD, Evans CA, Whetton AD (2006) Trends Biochem Sci 31:473–484

    Article  CAS  Google Scholar 

  9. Chelius D, Bondarenko PV (2002) J Proteome Res 1:317–323

    Article  CAS  Google Scholar 

  10. Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R (1999) Nat Biotechnol 17:994–999

    Article  CAS  Google Scholar 

  11. Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, Mann M (2002) Mol Cell Proteomics 1:376–386

    Article  CAS  Google Scholar 

  12. Szpunar J, Lobinski R, Prange A (2003) Appl Spectrosc 57:102A–111A

    Article  CAS  Google Scholar 

  13. Sanz-Medel A, Montes-Bayón M, Fernández Sánchez ML (2003) Anal Bioanal Chem 377:236–247

    Article  CAS  Google Scholar 

  14. Szpunar J (2005) Analyst 130:442–465

    Article  CAS  Google Scholar 

  15. Sanz-Medel A (2005) Anal Bioanal Chem 381:1–2

    Article  CAS  Google Scholar 

  16. Mestek O, Kominkova J, Koplik R, Kodicek M, Zima T (2007) Appl Organomet Chem 21:5–14

    Article  CAS  Google Scholar 

  17. Svantesson E, Pettersson J, Markides KE (2002) J Anal At Spectrom 17:491–496

    Article  CAS  Google Scholar 

  18. Pereira-Navaza A, Ruiz Encinar J, Sanz-Medel A (2007) J Anal At Spectrom. DOI 10.1039/b703555a

  19. Messerschmidt A, Huber R, Poulos T, Wieghardt K (eds) (2001) Handbook of metalloproteins, vols 1–3. Wiley, Chichester

  20. Lobinski R, Schaumlöffel D, Szpunar J (2006) Mass Spectrom Rev 25:255–289

    Article  CAS  Google Scholar 

  21. Wind M, Lehmann WD (2004) J Anal At Spectrom 19:20–25

    Article  CAS  Google Scholar 

  22. Quintana M, Coluda AD, Gondikas A, Ochsenkühn-Petropoulou M, Michalke B (2006) Anal Chim Acta 573–574:172–180

    Article  Google Scholar 

  23. Wang J, Dreessen D, Wiederin DR, Houk RS (2001) Anal Biochem 288:89–96

    Article  CAS  Google Scholar 

  24. Sanz-Medel A, Soldado Cabezuelo AB, Milacic R, Bantan Polak T (2002) Coord Chem Rev 228:373–383

    Article  CAS  Google Scholar 

  25. Nagaoka MH, Maitani T (2000) Analyst 125:1962–1965

    Article  CAS  Google Scholar 

  26. Wind M, Wesch H, Lehmann WD (2001) Anal Chem 73:3006–3010

    Article  CAS  Google Scholar 

  27. Wind M, Wegener A, Kellner R, Lehmann WD (2005) Anal Chem 77:1957–1962

    Article  CAS  Google Scholar 

  28. Krüger R, Wolschin F, Weckwerth, Bettmer J, Lehmann WD (2007) Biochem Biophys Res Commun 355:89–96

    Article  Google Scholar 

  29. Krüger R, Kübler D, Pallissé R, Burkovski A, Lehmann WD (2006) Anal Chem 78:1987–1994

    Article  Google Scholar 

  30. Helfrich A, Bettmer J (2007) J Anal At Spectrom 22:1296–1299

    Google Scholar 

  31. Garijo Añobe M, Messerschmidt J, Feldmann I, Jakubowski N (2007) J Anal At Spectrom 22:917–924

  32. Hann S, Koellensperger G, Obinger C, Furtmüller PG, Stingeder G (2004) J Anal At Spectrom 19:74–79

    Article  CAS  Google Scholar 

  33. Hagège A, Baldinger T, Martin-Jouet M, Zal F, Leroy M, Leize E, Van Dorsselaer A (2004) Rapid Commun Mass Spectrom 18:735–738

    Article  Google Scholar 

  34. Van Lierde V, Chéry CC, Strijckmans K, Galleni M, Devreese B, Van Beeumen J, Moens L, Vanhaecke F (2004) J Anal At Spectrom 19:888–893

    Article  Google Scholar 

  35. Takatera K, Watanabe T (1993) Anal Chem 65:759–762

    Article  CAS  Google Scholar 

  36. Michalke B, Schramel P (1999) Electrophoresis 20:2547–2553

    Article  CAS  Google Scholar 

  37. Shah M, Wuilloud RG, Kannamkumarath SS, Caruso J (2005) J Anal At Spectrom 20:176–182

    Article  CAS  Google Scholar 

  38. Wind M, Eisenmenger A, Lehmann WD (2002) J Anal At Spectrom 17:21–26

    Article  CAS  Google Scholar 

  39. Siethoff C, Feldmann I, Jakubowski N, Linscheid M (1999) J Mass Spectrom 34:421

    Article  CAS  Google Scholar 

  40. Axelsson B-O, Jörnten-Karlsson M, Michelsen P, Abou-Shakra F (2001) Rapid Commun Mass Spectrom 15:375–385

    Article  CAS  Google Scholar 

  41. Pereira Navaza A, Ruiz Encinar J, Sanz-Medel A (2007) Angew Chem Int Ed 46:569–571

    Article  CAS  Google Scholar 

  42. Kovacevic M, Goessler W, Mikac N, Veber M (2005) Anal Bioanal Chem 383:145–151

    Article  CAS  Google Scholar 

  43. Yanes EG, Miller-Ihli NJ (2004) Spectrochim Acta Part B 59:883–890

    Article  Google Scholar 

  44. Giusti P, Schaumlöffel D, Ruiz Encinar J, Szpunar J (2005) J Anal At Spectrom 20:1101–1107

    Article  CAS  Google Scholar 

  45. Pröfrock D, Leonard P, Ruck W, Prange A (2005) Anal Bioanal Chem 381:194–204

    Article  Google Scholar 

  46. Neilsen JL, Abildtrup A, Christensen J, Watson P, Cox A, McLeod CW (1998) Spectrochim Acta Part B 53:339–345

    Article  Google Scholar 

  47. Becker JS, Zoriy M, Krause-Buchholz U, Becker J, Pickhardt C, Przybylski M, Pompe W, Rödel G (2004) J Anal At Spectrom 19:1236–1243

    Article  CAS  Google Scholar 

  48. Becker JS, Zoriy M, Becker J, Pickhardt C, Damoc E, Juhacz G, Palkovits M, Przybylski M (2005) Anal Chem 77:5851–5860

    Article  CAS  Google Scholar 

  49. Elliot VL, McLeod CW, Marshall PS (2005) Anal Bioanal Chem 383:416–423

    Article  Google Scholar 

  50. Feldmann I, Koehler CU, Roos PH, Jakubowski N (2006) J Anal At Spectrom 21:1006–1015

    Article  CAS  Google Scholar 

  51. Lustig S, De Kimpe J, Cornelis R, Schramel P (1999) Fresenius J Anal Chem 363:484–487

    Article  CAS  Google Scholar 

  52. Ma RL, McLeod CW, Tomlinson K, Poole RK (2004) Electrophoresis 25:2469–2477

    Article  CAS  Google Scholar 

  53. Kastenholz B (2006) Protein Pept Lett 13:503–508

    Article  CAS  Google Scholar 

  54. Marshall P, Heudi O, Bains S, Freeman HN, Abou-Shakra F, Reardon K (2002) Analyst 127:459–461

    Article  CAS  Google Scholar 

  55. Wind M, Feldmann I, Jakubowski N, Lehmann WD (2003) Electrophoresis 24:1276–1280

    Article  CAS  Google Scholar 

  56. O’Connor C, Landon MR, Sharp BL (2007) J Anal At Spectrom 22:273–282

    Article  CAS  Google Scholar 

  57. Mayya V, Han DK (2006) Expert Rev Proteomics 3:597–610

    Article  CAS  Google Scholar 

  58. Lin SH, Shaler TA, Becker CH (2006) Anal Chem 78:5762–5767

    Article  CAS  Google Scholar 

  59. Rodríguez-González P, Marchante-Gayón JM, Alonso JIG, Sanz-Medel A (2005) Spectrochim Acta Part B 60:151–207

    Article  Google Scholar 

  60. Rottmann L, Heumann KG (1994) Anal Chem 66:3709–3715

    Article  CAS  Google Scholar 

  61. Heumann KG, Rottmann L, Vogl J (1994) J Anal At Spectrom 9:1351–1355

    Article  CAS  Google Scholar 

  62. Huerta VD, Sanchez MLF, Sanz-Medel A (2006) Anal Bioanal Chem 384:902–907

    Article  Google Scholar 

  63. Huerta VD, Reyes LH, Marchante-Gayón JM, García-Alonso JI, Sanz-Medel A (2003) J Anal At Spectrom 18:1243–1247

    Article  Google Scholar 

  64. Rodríguez-Cea A, de la Campa MRF, Gonzalez EB, Fernandez BA, Sanz-Medel A (2003) J Anal At Spectrom 18:1357–1364

    Article  Google Scholar 

  65. Goenaga Infante H, Van Campenhout K, Schaumlöffel D, Blust R, Adams FC (2003) Analyst 128:651–657

    Article  CAS  Google Scholar 

  66. Polec-Pawlak K, Schaumlöffel D, Szpunar J, Prange A, Lobinski R (2002) J Anal At Spectrom 17:908–912

    Article  CAS  Google Scholar 

  67. Ferrarello CN, Ruiz Encinar J, Centineo G, Alonso JIG, de la Campa MRF, Sanz-Medel A (2002) J Anal At Spectrom 17:1024–1029

    Article  CAS  Google Scholar 

  68. Prange A, Schaumlöffel, D, Brätter P, Richarz AN, Wolf C (2001) Fresenius J Anal Chem 371:764–774

    Article  CAS  Google Scholar 

  69. Schaumlöffel D, Prange A, Marx G, Heumann KG, Brätter P (2002) Anal Bioanal Chem 372:155–163

    Article  Google Scholar 

  70. Wang Z, Prange A (2002) Anal Chem 74:626–631

    Article  CAS  Google Scholar 

  71. Sariego Muñiz C, Marchante-Gayón JM, García-Alonso JI, Sanz-Medel A (2001) J Anal At Spectrom 16:587–592

    Article  Google Scholar 

  72. Hinojosa Reyes L, Marchante-Gayón JM, García-Alonso JI, Sanz-Medel A (2003) J Anal At Spectrom 18:1210–1216

    Article  CAS  Google Scholar 

  73. Havlis J, Schevchenko A (2004) Anal Chem 76:3029–3036

    Article  CAS  Google Scholar 

  74. Harrington CF, Vidler DS, Watts MJ, Hall JF (2005) Anal Chem 77:4034–4041

    Article  CAS  Google Scholar 

  75. Hann S, Obinger C, Stingeder G, Paumann M, Furtmüller PG, Koellensperger G (2006) J Anal At Spectrom 21:1224–1231

    Article  CAS  Google Scholar 

  76. Del Castillo Busto ME, Montes-Bayón M, Sanz-Medel A (2006) Anal Chem 82:8218–8226

    Article  Google Scholar 

  77. Polatajko A, Ruiz Encinar J, Schaumlöffel D, Szpunar J (2005) Chem Anal (Warsaw) 50:265–278

    CAS  Google Scholar 

  78. Schaumlöffel D, Giusti P, Preud’Homme H, Szpunar J, Lobinski R (2007) Anal Chem 79:2859–2868

    Article  Google Scholar 

  79. Rodríguez-Cea A, Fernández de la Campa MR, García Alonso JI, Sans Medel A (2006) J Anal At Spectrom 21:270–278

    Article  Google Scholar 

  80. Suzuki KT, Doi C, Suzuki N (2006) Toxicol Appl Pharmacol 217:185–195

    Article  CAS  Google Scholar 

  81. Suzuki KT, Somekawa L, Kurasaki K, Suzuki N (2006) J Health Sci 52:590–597

    Article  CAS  Google Scholar 

  82. Shi JW, Feng WY, Wang M, Zhang F, Li B, Wang B, Zhu MT, Chai ZF (2007) Anal Chim Acta 583:84–91

    Article  CAS  Google Scholar 

  83. Bettmer J, Jakubowski N, Prange A (2006) Anal Bioanal Chem 386:7–11

    Article  Google Scholar 

  84. Marshall P, Heudi O, Mckeown S, Amour A, Abou-Shakra F (2002) Rapid Commun Mass Spectrom 16:220–228

    Article  CAS  Google Scholar 

  85. Heudi O, Ramirez-Molina C, Marshall C, Amour A, Peace S, Mckeown S, Abou-Skakra F (2002) J Pept Sci 8:591–600

    Article  CAS  Google Scholar 

  86. Goshe MB, Smith RD (2003) Curr Opin Biotechnol 14:101–109

    Article  CAS  Google Scholar 

  87. Tao WA, Aebersold R (2003) Curr Opin Biotechnol 14:110–118

    Article  CAS  Google Scholar 

  88. Leitner A, Lindner W (2004) J Chromatogr 813:1–26

    Article  CAS  Google Scholar 

  89. Leitner A, Lindner W (2006) Proteomics 6:5418–5434

    Article  CAS  Google Scholar 

  90. Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, Purkayastha S, Juhasz P, Martin S, Bartlet-Jones M, He F, Jacobson A, Pappin DJ (2004) Mol Cell Proteomics 3:1154–1169

    Article  CAS  Google Scholar 

  91. Whetstone PA, Butlin NB, Corneillie TM, Meares CF (2004) Bioconj Chem 15:3–6

    Article  CAS  Google Scholar 

  92. Liu H, Zhang Y, Wang J, Wang D, Zhou C, Cai Y, Qian X (2006) Anal Chem 78:6614–6621

    Article  CAS  Google Scholar 

  93. Linscheid M, Pieper S, Ahrends R, Weisshof H, Hamester M, Lindemann T, Scheler C (2006) Presentation at the 54th ASMS conference on mass spectrometry and allied topics, Seattle, WA, 26 May–1 June 2006

  94. Patel P, Jones P, Handy R, Harrington C, Marshall P, Evans EH (2007) Anal Bioanal Chem. DOI 10.1007/s00216-007-1432-7

  95. Zhang C, Zhang Z, Yu B, Shi J, Zhang X (2002) Anal Chem 74:96–99

    Article  CAS  Google Scholar 

  96. Baranov VI, Quinn Z, Bandura DR, Tanner SD (2002) Anal Chem 74:1629–1636

    Article  CAS  Google Scholar 

  97. Quinn ZA, Baranov VI, Tanner SD, Wrana JL (2002) J Anal At Spectrom 17:892–896

    Article  CAS  Google Scholar 

  98. Zhang C, Wu F, Zhang X (2002) J Anal At Spectrom 17:1304–1307

    Article  CAS  Google Scholar 

  99. Zhang S, Zhang C, Xing Z, Zhang X (2004) Clin Chem 50:1214–1221

    Article  CAS  Google Scholar 

  100. Ornatsky O, Baranov VI, Bandura DR, Tanner SD, Dick J (2006) J Immunol Methods 308:68–76

    Article  CAS  Google Scholar 

  101. Tanner SD, Ornatsky O, Bandura DR, Baranov VI (2007) Spectrochim Acta B 62:188–195

    Article  Google Scholar 

  102. Müller SD, Diaz-Bone RA, Felix J, Goedecke W (2005) J Anal At Spectrom 20:907–911

    Article  Google Scholar 

  103. Hu S, Zhang S, Hu Z, Xing Z, Zhang X (2007) Anal Chem 79:923–929

    Article  CAS  Google Scholar 

  104. Helfrich A, Brüchert W, Bettmer J (2006) J Anal At Spectrom 21:431–434

    Article  CAS  Google Scholar 

  105. Griffin TJ, Aebersold, R (2001) J Biol Chem 276:45497–45500

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, C/Julián Clavería 8, 33006, Oviedo, Spain

    Alfredo Sanz-Medel, María Montes-Bayón, María del Rosario Fernández de la Campa, Jorge Ruiz Encinar & Jörg Bettmer

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  1. Alfredo Sanz-Medel
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  2. María Montes-Bayón
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  3. María del Rosario Fernández de la Campa
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  4. Jorge Ruiz Encinar
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Correspondence to Alfredo Sanz-Medel.

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Sanz-Medel, A., Montes-Bayón, M., del Rosario Fernández de la Campa, M. et al. Elemental mass spectrometry for quantitative proteomics. Anal Bioanal Chem 390, 3–16 (2008). https://doi.org/10.1007/s00216-007-1615-2

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