Abstract
This article reviews various methods of modifying the bulk and surface properties of poly(lactic acid) (PLA) so that the polymer may be used as a drug carrier in a drug delivery system (DDS) and as a cell scaffold in tissue engineering. Copolymerization of lactide with other lactone-type monomers or monomers with functional groups such as malic acid, copolymerization of lactide with macromolecular monomer such as poly(ethylene glycol) (PEG) or dextran, as well as blending polylactide and natural derivatives and other methods of bulk modification are discussed. Surface modifications of PLA-type copolymers, such as surface coating, chemical modification, and plasma treatment are described. Cell culture technology proves the efficiency of bulk and surface modification and the potential application of PLA in tissue engineering.
Similar content being viewed by others
References
Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM (1999) Chem Rev 99:3181–3198
Jurgens CH, Kricheldorf HR, Kreiser-Saunders I (1998) Development of a biodegradable wound covering and first clinical results. In: Walenkamp GHIM (ed) Biomaterials in surgery. Thieme-Verlag, New York, pp 112–120
Leenslag JW, Pennings AJ, Bos RR, Rozema FR, Boering G (1987) Biomaterials 8:70–73
Shi FY, Gross RA, Rutherford DR (1996) Micromolecules 29:10–17
Shi FY, Ashby R, Gross RA (1996) Macromolecules 29:7753–7758
Kronenthal RL (1974) Biodegradable polymers in medicine and surgery. In: Kronenthal RL, User Z, Martin E (ed) Polymers in medicine and surgery. Plenum, New York, pp 119–137
Wang SG, Cai Q, Bei JZ (2003) Macromol Symp 195:263–268
Vert M, Li S, Spenlehauer G, Guerin P (1992) J Mater Sci Mater Med 3:432–446
Marshall D (1998) European Plastics News (March), pp 23–24
Wang SG, Cui WJ, Li GM, Cai Q, Zhi G, Zhao YY, Yang B, Xu Y (2003) China 46:371–378
Wang SG, Cai Q, Hou JW, Bei JZ, Zhang T, Yang J, Wan YQ (2003) J Biomed Mater Res 66A:522–531
Wang SG (1997) Chem Commun 2:45–47
Cao X, Shoichet MS (1999) Biomaterials 20:329–339
Mooney DJ, Breuer MD, Mcnamara K, Vacanti JP, Langer R (1995) Tissue Eng 1:107–118
Qian HT, Bei JZ, Wang SG (2000) Polym Degrad Stab 68:423–429
Cai Q, Bei JZ, Wang SG (2000) J Biomed Sci Polym Ed 11:273–288
Wang SG, Wan YQ, Cai Q, He B, Chen WN (2004) Chem Res Chin Univ 20:191–194
Deasi NP, Hubbell JA (1991) J Biomed Mater Res 25:829–834
Fuerteges F, Abuchowski A (1990) J Control Release 11:139–148
Yokoyama M, Okano R, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K (1991) Cancer Res 51:3229–3236
Cohn D, Younes H (1988) J Biomed Mater Res 22:993–995
Deng XM, Xiong CD (1990) J Polym Sci Polym Lett Ed 28:411–416
Ferruti P, Penco M, D’Addato P, Ranucci E, Deghenghi R (1995) Biomaterials 16:1423–1428
Penco M, Marcioni S, Ferruti P, D’ Antone SR (1996) Biomaterials 17:1583–1590
Krickeldorf HR, Haack JM (1993) Macromol Chem Phys 194:715–725
Krickeldorf HR, Boettcher C (1993) Mackromol Chem Mackromol Symp 73:47–51
Stevels WM, Ankone, MJK, Dijkstra PJ, Feijen J (1995) Macromol Chem Phys 196:3687–3694
Cerrai P, Tricoli M, Lelli L, Guerra GD, Sbarbati D, Guerra R, Casone MG, Giusti P (1994) J Mater Sci Mater Med 5:308–316
Cai Q, Bei JZ, Wang SG (2000) Polym Adv Technol 11:156–166
Soo HE, Soo HK, Yang KH, Young HK (2002) J Polym Sci Pol Chem 40:2545–2555
Zhu Z, Xiong C, Zhang L, Yuan M, Deng X (1999) Eur Polym J 35:1821–1828
Luo WJ, Li SM, Wang SG, Bei JZ (2002) J Appl Polym Sci 84:1729–1736
Chen WN, Luo WJ, Wang SG, Bei JZ (2003) Polym Advan Technol 14:245–253
Lang MD, Bei JZ, Wang SG (1999) J Biomat Sci–Polym E 4:501–512
Chen DR, Chen HL, Wang SG, Bei JZ (2000) Polym Int 49:269–276
Chen HL, Bei JZ, Wang SG (2000) Polym Advan Technol 11:180–184
Michael AC, Mark WG (2001) J Am Chem Soc 123:2905–2906
Li YX, Kissel T (1998) Polymer 39:4421–4427
Pistel KF, Bittner B, Koll H, Winter G, Kissel T (1999) J Control Release 59:309–325
Roberts JC, Bhalgat MK, Zera RT (1996) J Biomed Mater Res 30:53–65
Zhao YL, Cai Q, Jiang J, Shuai XT, Bei JZ, Chen CF, Xi F (2002) Polymer 43:5819–5825
Cai Q, Zhao YL, Wang SG, Bei JZ (2003) Biomacromolecules 4:828–834
Béar MM, Randriamahefa S, Langlois V, Guérin Ph (2000) Polymer 41:3705–3712
Moine L, Cammas S, Amiel C, Guerin P, Sebille B (1997) Polymer 38:3121–3127
Osanai S, Nakamura K (2000) Biomaterials 21:867–876
Kimura Y, Shirotani K, Yamane H, Kitao T (1993) Polymer 34:1741–1748
He B, Bei JZ, Wang SG (2003) Polymer 44:989–994
Reis RL, Cunba AM (1995) J Mater Sci Mater Med 6:786–792
Gomes ME, Riberio AS, Malafaya PB, Reis RL, Cunba AM (2001) Biomaterials 22:883–889
Gomes ME, Reis RL, Cunba AM, van Blitterswijk CA, de Bruijn JD (2001) Biomaterials 22:1911–1917
Mendes SC, Reis RL, Bonvell YP, Cunba AM, van Blitterswijk CA, de Bruijn JD (2001) Biomaterials 22:2057–2064
Cai Q, Wan YQ, Wang SG, Bei JZ (2003) Biomaterials 24:3555–3562
Cai Q, Yang J, Wang SG, Bei JZ (2002) Biomaterials 23:4483–4492
Dodane V, Vilivalam VD (1998) Pharmaceutical applications of chitosan. Pharm Sci Tech Today 1:246–253
Qu X, Wirsen A, Albertsson AC (1999) J Appl Polym Sci 74:3193–3202
Liu Y, Tian F, Hu KA (2004) Carbohydr Res 339:845–851
Tamada Y, Ikada Y (1994) J Biomed Mater Res 28:783–789
van Wachem PB, Hogt AH, Beugeling T, Feijen J, Bantjes A, Detmers JP, van Aken WG (1987) Biomaterials 8:323–328
Horbett T, Schway M, Ratner B (1985) J Colloid Interf Sci 104:28–39
Dimilla PA, Stone JA, Wuinn JA (1993) J Cell Biol 122:729–734
Massia SP, Hubbell JA (1991) J Biomed Mater Res 25:223–242
Lin H, Sun W, Mosher DF, Garcia-Echeverria C, Schaufelberger K, Lelkes PI, Cooper SL (1994) J Biomed Mater Res 28:329–342
Drumheller PD, Ebert DL, Hubbell JA (1994) Biotech Bioeng 43:772–780
Otsuka H, Nagasaki Y, Kataoka K (2000) Biomacromolecules 1:39–48
Yang J, Wan YQ, Wang SG, Tu CF, Cai Q, Bei JZ (2003) Polym Int 52:1892–1899
Barrera DA, Zylstra E, Lansbury PT, Langer R (1993) J Am Chem Soc 115:11010–11011
Feast WJ, Munro S, Richards RW (eds) (1993) Polymer surfaces and interfaces II. Wiley, New York
Loh IH (1993) J Polym 34:661–662 (preprint)
Wade WL, Mammone RJ, Binder M (1991) J Appl Polym Sci 43:1589–1591
Occhiello E, Morra M, Morini G, Garbassi F, Humphrey P (1991) J Appl Polym Sci 42:551–559
Favia P, d’Agostino R (1998) Surf Coat Tech 98:1102–1106
Kang ET, Tan KL, Kato K, Uyama Y, Ikada Y (1996) Macromolecules 29:6872–6879
Qiu YX, Klee D, Plüster W, Severich B, Hőcker H (1996) J Appl Polym Sci 61:2373–2382
Hsu SH, Chen WC (2000) Biomaterials 21:359–367
Yang J, Shi GX, Wang SG, Bei JZ, Cao YL, Shang QX, Yang GH, Wang WJ (2002) J Biomed Mater Res 62:438–446
Yang J, Bei JZ, Wang SG (2002) Biomaterials 23:2607–2614
Yang J, Wan YQ, Wang SG, Yang JL, Bei JZ (2003) J Biomed Mater Res 67A:1139–1147
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, S., Cui, W. & Bei, J. Bulk and surface modifications of polylactide. Anal Bioanal Chem 381, 547–556 (2005). https://doi.org/10.1007/s00216-004-2771-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00216-004-2771-2