Skip to main content
SpringerLink
Log in

Response to the opinion letter entitled Role of Ferroptosis in Acetaminophen Hepatotoxicity by Yamada et al.

  • Letter to the Editor, News and Views
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

A Letter to the Editor, News and Views to this article was published on 16 March 2020

A Review Article was published on 22 October 2019

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Cover C, Mansouri A, Knight TR et al (2005) Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther 315:879–887

    Article  CAS  Google Scholar 

  • Du K, Farhood A, Jaeschke H (2017) Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol 91:761–773. https://doi.org/10.1007/s00204-016-1692-0

    Article  CAS  PubMed  Google Scholar 

  • Jaeschke H, Kleinwaechter C, Wendel A (1987) The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice. Biochem Pharmacol 36:51–57

    Article  CAS  Google Scholar 

  • Jaeschke H, Ramachandran A, Chao X, Ding WX (2019) Emerging and established modes of cell death during acetaminophen-induced liver injury. Arch Toxicol 93:3491–3502. https://doi.org/10.1007/s00204-019-02597-1

    Article  CAS  PubMed  Google Scholar 

  • Jaeschke H, Akakpo JY, Umbaugh DS, Ramachandran A (2020) Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure. Toxicol Sci 174:159–167. https://doi.org/10.1093/toxsci/kfaa002

    Article  PubMed  Google Scholar 

  • Knight TR, Fariss MW, Farhood A, Jaeschke H (2003) Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice. Toxicol Sci 76:229–236

    Article  CAS  Google Scholar 

  • Knight TR, Ho YS, Farhood A, Jaeschke H (2002) Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione. J Pharmacol Exp Ther 303:468–475

    Article  CAS  Google Scholar 

  • Mathews WR, Guido DM, Fisher MA, Jaeschke H (1994) Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia. Free Radic Biol Med 16:763–770

    Article  CAS  Google Scholar 

  • Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H (2011) The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 251:226–233. https://doi.org/10.1016/j.taap.2011.01.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wendel A, Feuerstein S (1981) Drug-induced lipid peroxidation in mice–I. Modulation by monooxygenase activity, glutathione and selenium status. Biochem Pharmacol 30:2513–2520

    Article  CAS  Google Scholar 

  • Yamada N, Karasawa T, Kimura H et al (2020) Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Cell Death Dis 11:144. https://doi.org/10.1038/s41419-020-2334-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Kansas Medical Center, Kansas City, KS, USA

    Hartmut Jaeschke & Anup Ramachandran

Authors
  1. Hartmut Jaeschke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anup Ramachandran
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hartmut Jaeschke.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jaeschke, H., Ramachandran, A. Response to the opinion letter entitled Role of Ferroptosis in Acetaminophen Hepatotoxicity by Yamada et al.. Arch Toxicol 94, 1771–1772 (2020). https://doi.org/10.1007/s00204-020-02723-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00204-020-02723-4

Search

Navigation