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The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery

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Abstract

Nanotechnology is a rapidly growing area of research in part due to its integration into many biomedical applications. Within nanotechnology, gold and silver nanostructures are some of the most heavily utilized nanomaterial due to their unique optical, photothermal, and facile surface chemical properties. In this review, common colloid synthesis methods and biofunctionalization strategies of gold and silver nanostructures are highlighted. Their unique properties are also discussed in terms of their use in biodiagnostic, imaging, therapeutic, and drug delivery applications. Furthermore, relevant clinical applications utilizing gold and silver nanostructures are also presented. We also provide a table with reviews covering related topics.

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Acknowledgments

MAE and coworkers would like to acknowledge the support from the U.S. National Institutes of Health (1U01CA151802-01). LAA thanks the support from Georgia Institute of Technology/Department of Education’s Graduate Assistance in Areas of National Need (GAANN) Molecular Biophysics and Biotechnology Fellowship. ECD acknowledges postdoctoral fellowship support from the NIH (Ruth L. Kirschstein NRSA 1F32EB017614-01).

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Authors and Affiliations

  1. Laser Dynamics Laboratory, Department of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Dr. NW, Atlanta, GA, 30332-0400, USA

    Lauren A. Austin, Megan A. Mackey & Mostafa A. El-Sayed

  2. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 500 Main St., Cambridge, MA, 02139, USA

    Erik C. Dreaden

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  1. Lauren A. Austin
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  2. Megan A. Mackey
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  3. Erik C. Dreaden
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  4. Mostafa A. El-Sayed
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Correspondence to Mostafa A. El-Sayed.

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Austin, L.A., Mackey, M.A., Dreaden, E.C. et al. The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery. Arch Toxicol 88, 1391–1417 (2014). https://doi.org/10.1007/s00204-014-1245-3

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  • DOI: https://doi.org/10.1007/s00204-014-1245-3

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