Abstract
3-Monochloropropane-1, 2-diol (or 3-chloro-1,2-propanediol, 3-MCPD) is a well-known food processing contaminant found in a wide range of foods and ingredients. It has been classified as non-genotoxic carcinogen but its carcinogenic potential in the rodents has been controversial. The carcinogenicity to B6C3F1 mice by drinking water administration was assessed over a period of 104 weeks. Three groups, each comprising 50 male and 50 female mice received 3-MCPD at dosages of 30, 100 or 300 ppm up to Day 100 and 200 ppm onward (4.2, 14.3 and 33.0 mg/kg for males; 3.7, 12.2, and 31.0 mg/kg for females), were allocated. Survival was good, with at least 80% of males and 72% of females in each group surviving 104 weeks. Body weights and body weight gain were decreased in males and females receiving 200 ppm. Water and food consumptions of both sexes at 300/200 ppm were lowered. Emaciated or crouching position was observed for animals of both sexes exposed to 200 ppm. There were some differences in hematology and serum biochemistry compared with controls, although there was no histopathological evidence to support those changes. Histopathological examination did not reveal any neoplastic or non-neoplastic findings attributable to treatment with 3-MCPD. It is concluded that drinking water administration of 3-MCPD for 104 weeks revealed no evidence of carcinogenic potential.
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Abbreviations
- CPN:
-
Chronic Progressive Nephropathy
- KFDA:
-
Korea Food and Drug Administration
- KIT:
-
Korea Toxicology Institute
- NOAEL:
-
No-Observed-Adverse-Effect Level
- 3-MCPD:
-
3-Monochloropropane-1, 2-diol
- MTD:
-
Maximum Tolerated Dose
- OECD:
-
Organisation for Economic Co-operation and Development
- SCF:
-
Scientific Committee on Food
- SD:
-
Spargue-Dawley
- TDI:
-
Tolerable Daily Intake
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Acknowledgments
This work was supported by a grant (04122KFDA242, 05122KFDA489, 06132KFDA378, 07142KFDA554) from Korea Food & Drug Administration for the National Toxicology Program in Korea (KNTP). The technical assistance provided by KIT staff is gratefully acknowledged.
Conflict of interest statement
This paper has no conflict of interest (Financial, personal, or relationships with other people or organizations within 3 years of beginning the work submitted that could inappropriately influence the work submitted).
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J. Jeong and B. S. Han contributed equally.
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Jeong, J., Han, B.S., Cho, WS. et al. Carcinogenicity study of 3-monochloropropane-1, 2-diol (3-MCPD) administered by drinking water to B6C3F1 mice showed no carcinogenic potential. Arch Toxicol 84, 719–729 (2010). https://doi.org/10.1007/s00204-010-0552-6
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DOI: https://doi.org/10.1007/s00204-010-0552-6