Abstract
More than 2,000 arsenic-related skin lesions (as at 2002) in a few villages of China’s Southwest Guizhou Autonomous Prefecture represent a unique case of endemic arseniasis related with indoor combustion of high-arsenic coal. The skin lesion prevalence was significantly higher in ethnic Han villagers than in ethnic Hmong villagers. This study was focused on a possible involvement of XPD/ERCC2 G 23591 A and A 35931 C polymorphisms in risk modulation of skin lesions and in the body burden of As in this unique case of As exposure. G 23591 A and A 35931 C were genotyped by a PCR-based procedure. Total As contents in hair and urine samples as well as environmental samples of the homes of the two ethnic clans were analysed. A significant higher presentation of A/A 35931 (homozygous wild) genotype in both clans was found in skin lesion patients, compared with their asymptomatic fellow villagers (67.1 vs. 46.3%, OR 2.36, 95% CI 1.35–4.14, P = 0.002). Interestingly, the population frequencies of the A/A 35931 genotype did not show significant differences between ethnic Han villagers and their Hmong neighbours (47.1 vs. 45.5%). Very low frequencies of homozygous and heterozygous variant genotypes of G 23591 A were recorded in the residents in target village. G/A 23591 and A/A 23591 were detected only in 3.2% (8/244) and 0.8% (2/244) of the villagers, respectively. The polymorphic status at the locus of A 35931 C might modulate the risk for arsenic-related skin lesions in the investigated groups.
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Lin, Gf., Du, H., Chen, Jg. et al. Association of XPD/ERCC2 G 23591 A and A 35931 C polymorphisms with skin lesion prevalence in a multiethnic, arseniasis-hyperendemic village exposed to indoor combustion of high arsenic coal. Arch Toxicol 84, 17–24 (2010). https://doi.org/10.1007/s00204-009-0474-3
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DOI: https://doi.org/10.1007/s00204-009-0474-3