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The determinants of bone mineral density in Chinese men—results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men

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Abstract

Mr. Os (Hong Kong) is the first study to address the risk factors for osteoporosis in Asian men. A standardized, structured interview and dual X-ray densitometry (DEXA) were performed on 2,000 Chinese men aged 65–92. By multiple regression, the following factors were found to be positively associated with BMD at both the total hip and the spine: body weight, grip strength and a history of diabetes mellitus. The following factors were found to be negatively associated with BMD at both the total hip and spine: cigarette smoking, a history of gastrectomy or bowel resection, current use of inhaled steroid and a history of fracture after 50 years. Moreover, a history of chronic obstructive pulmonary disease (COPD) was negatively associated with BMD at the total hip, and age, the use of an alpha-blocker, thiazide diuretic and nitrate were associated with a higher BMD at the spine. A total of 21.8% of the variance in total hip and 31.5% of the variance in total spine BMD was accounted for in the multivariate analysis.

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Acknowledgements

The authors would like to thank Ms. Peggy Cawthon (of the University of California, San Francisco) and Ms. Athena Hong (of the Chinese University of Hong Kong) for their assistance in coordinating Mr. Os (Hong Kong) and Mr. Jason Leung for conducting the data analysis. The research was supported by the Research Grants Council of Hong Kong and National Institute of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases grant reference 1 RO1 AR049439–01 A1.

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Authors and Affiliations

  1. Hong Kong Orthopaedic and Osteoporosis Center for Treatment and Research, Unit 1301, Hing Wai Building, 36 Queen’s Road Central, Hong Kong, China

    E. M. C. Lau

  2. Department of Orthopedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, China

    P. C. Leung

  3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China

    T. Kwok & J. Woo

  4. School of Public Health, The Chinese University of Hong Kong, Hong Kong, China

    H. Lynn

  5. Department of Endocrinology and Metabolism, Oregon Health Sciences University, Portland, OR, USA

    E. Orwoll

  6. Department of Medicine, University of California, San Francisco, CA, USA

    S. Cummings

  7. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA

    J. Cauley

Authors
  1. E. M. C. Lau
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  2. P. C. Leung
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  3. T. Kwok
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  4. J. Woo
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  5. H. Lynn
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  6. E. Orwoll
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  7. S. Cummings
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  8. J. Cauley
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Correspondence to E. M. C. Lau.

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Lau, E.M.C., Leung, P.C., Kwok, T. et al. The determinants of bone mineral density in Chinese men—results from Mr. Os (Hong Kong), the first cohort study on osteoporosis in Asian men. Osteoporos Int 17, 297–303 (2006). https://doi.org/10.1007/s00198-005-2019-9

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  • DOI: https://doi.org/10.1007/s00198-005-2019-9

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