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Characteristics and course of bone mineral densities among fast bone losers in a rural Japanese community: the Miyama Study

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Abstract

The aim of this study was to clarify and compare the temporal course of bone mineral density (BMD) between fast bone losers and normal residents in Miyama Village, a rural Japanese community. BMD was measured over a 10-year period in a cohort study in Miyama Village, Wakayama Prefecture, Japan, to provide information on rate of bone loss in the mature and elderly population. Subjects (n=400) were selected by sex and age stratum from the full list of residents born in 1910–1949, with 50 men and 50 women in each age decade. Baseline BMD of the lumbar spine and proximal femur was measured using dual energy X-ray absorptiometry in 1990, 1993, 1997 and 2000. In the cohort, 171 men and 189 women completed the follow-up survey performed in 1993. After calculating the rate of bone loss between 1990 and 1993, the greatest tertile from the distribution of bone loss was categorized as fast bone losers, with the remainder considered as normal subjects. Changes in BMD were compared between normal subjects and fast bone losers over the 10-year period. Mean rate of change for BMD at both lumbar spine and femoral neck in fast bone losers recovered to levels similar to those in normal subjects over 7 years of observation. By contrast, BMD at the lumbar spine and femoral neck decreased steeply over the 10-year period in both groups, and mean BMD for fast bone losers was significantly lower than that of normal subjects (P<0.05). These differences were apparent only at the lumbar spine in both men and women, even after adjusting for age. These results indicate that fast bone loss is a transient phenomenon rather than a fixed status, although individuals who have been categorized as fast bone losers at some stage continue to display low BMD in the lumbar spine.

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Acknowledgements

This work was supported by Grant-in-Aids for Scientific Research A09770272 and C2 13670383 from the Ministry of Education, Culture, Sports, Science and Technology and H12-Chojyu-025 from the Ministry of Health, Labour and Welfare in Japan. Noriko Yoshimura received a Grant for Young Investigators in 1999 from the Japanese Society of Bone Morphometry. The authors wish to thank members of the public office of Miyama Village for assistance in arranging the location and schedule for examinations. We are grateful to Dr. S. Tokunaga, Department of Preventive Medicine, Kyushu University, for his valuable advice concerning the analysis of the data in the present study.

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Authors and Affiliations

  1. Department of Public Health, Wakayama Medical University School of Medicine, 811-1 Kimiidera, 641-0012, Wakayama, Japan

    Noriko Yoshimura, Tomoko Takijiri, Seiji Morioka, Kiyomi Sakata & Tatsuya Takeshita

  2. Department of Orthopaedics, Saiseikai Wakayama Hospital, Wakayama, Japan

    Hirofumi Kinoshita

  3. Department of Orthopaedics, Saiseikai Arita Hospital, Arita, Japan

    Shigeto Danjoh

  4. Department of Health Science, Kobe City College of Nursing, Kobe, Japan

    Takahiro Kasamatsu

  5. Wakayama Red Cross Blood Center, Wakayama, Japan

    Tsutomu Hashimoto

Authors
  1. Noriko Yoshimura
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  2. Tomoko Takijiri
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  3. Hirofumi Kinoshita
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  4. Shigeto Danjoh
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  5. Takahiro Kasamatsu
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  6. Seiji Morioka
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  7. Kiyomi Sakata
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  8. Tsutomu Hashimoto
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  9. Tatsuya Takeshita
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Correspondence to Noriko Yoshimura.

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Yoshimura, N., Takijiri, T., Kinoshita, H. et al. Characteristics and course of bone mineral densities among fast bone losers in a rural Japanese community: the Miyama Study. Osteoporos Int 15, 139–144 (2004). https://doi.org/10.1007/s00198-003-1518-9

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  • DOI: https://doi.org/10.1007/s00198-003-1518-9

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